TY - JOUR
T1 - Structural and Functional Correlates of Myocardial T1 Mapping in 321 Patients with Hypertrophic Cardiomyopathy
AU - Chu, Linda C.
AU - Corona-Villalobos, Celia P.
AU - Halushka, Marc K.
AU - Zhang, Yan
AU - Pozzessere, Chiara
AU - Kamel, Ihab R.
AU - Pozios, Iraklis
AU - Van Der Geest, Rob J.
AU - Gai, Neville
AU - Abraham, Roselle M.
AU - Abraham, Theodore P.
AU - Bluemke, David A.
AU - Zimmerman, Stefan L.
N1 - Publisher Copyright:
© 2017 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Objective The aim of this study was to evaluate the structural and functional correlates of T1 mapping in 321 patients with hypertrophic cardiomyopathy (HCM). Methods Three hundred twenty-one patients with HCM who underwent cardiac magnetic resonance from 2003 to 2013 were retrospectively identified from our institution's HCM registry. Left ventricular volume, function, late gadolinium enhancement (LGE), and Look-Locker T1 time were quantified. T1 time was normalized to blood pool to calculate T1 ratio. Correlations between LGE%, T1 ratio, and structural and functional features were performed using Pearson correlation coefficient. Results Late gadolinium enhancement showed stronger correlation with left ventricular mass index (r = 0.41, P < 0.001) compared with T1 ratio (r = -0.17, P = 0.004). Both LGE% and T1 ratio correlated with ejection fraction (r = -0.18 and P = 0.002 vs r = 0.21 and P < 0.001, respectively). E/e' showed correlation with LGE% but not with T1 ratio. Conclusions Late gadolinium enhancement was more strongly correlated with the phenotypic expression of HCM compared with T1 ratio.
AB - Objective The aim of this study was to evaluate the structural and functional correlates of T1 mapping in 321 patients with hypertrophic cardiomyopathy (HCM). Methods Three hundred twenty-one patients with HCM who underwent cardiac magnetic resonance from 2003 to 2013 were retrospectively identified from our institution's HCM registry. Left ventricular volume, function, late gadolinium enhancement (LGE), and Look-Locker T1 time were quantified. T1 time was normalized to blood pool to calculate T1 ratio. Correlations between LGE%, T1 ratio, and structural and functional features were performed using Pearson correlation coefficient. Results Late gadolinium enhancement showed stronger correlation with left ventricular mass index (r = 0.41, P < 0.001) compared with T1 ratio (r = -0.17, P = 0.004). Both LGE% and T1 ratio correlated with ejection fraction (r = -0.18 and P = 0.002 vs r = 0.21 and P < 0.001, respectively). E/e' showed correlation with LGE% but not with T1 ratio. Conclusions Late gadolinium enhancement was more strongly correlated with the phenotypic expression of HCM compared with T1 ratio.
KW - T1 mapping
KW - cardiac magnetic resonance
KW - hypertrophic cardiomyopathy
KW - late gadolinium enhancement
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U2 - 10.1097/RCT.0000000000000564
DO - 10.1097/RCT.0000000000000564
M3 - Article
C2 - 27997439
AN - SCOPUS:85006415495
SN - 0363-8715
VL - 41
SP - 653
EP - 660
JO - Journal of computer assisted tomography
JF - Journal of computer assisted tomography
IS - 4
ER -