@article{a433d3a20747438ba434b8b92e67cc90,
title = "Structural and functional analysis of the murine adenosine deaminase gene",
abstract = "We describe the structural and functional analysis of cosmid clones that span the entire murine adenosine deaminase gene. Functional analysis indicated that these clones are capable of encoding murine adenosine deaminase activity when introduced into human cell lines. Structural analysis revealed that the gene consists of 12 exons distributed over approximately 25 kb. The exact size of each exon and the sequence of each exon/intron junction were determined. The results show that the 1056-nucleotide open reading frame for adenosine deaminase extends from exon 1 to exon 11, and that exon 12 contains untranslated sequences only. During the course of these investigations, we discovered that a gene encoding an abundant 1.3-kb polyadenylated transcript overlaps the 3′ end of the murine adenosine deaminase gene and is transcribed from the opposite strand.",
author = "Al-Ubaidi, {Muayyad R.} and V. Ramamurthy and Maa, {Ming Chei} and Ingolia, {Diane E.} and Chinsky, {Jeffrey M.} and Martin, {Brita D.} and Kellems, {Rodney E.}",
note = "Funding Information: This research was supported by Grants GM30204 and AI25255 from the National Institutes of Health, Q-893 from the Robert A. Welch Foundation, and a grant from Eli Lilly & Co. M.R.A. was a Robert A. Welch Predoctoral Fellow. V.R. was supported by a Postdoctoral Fellowship from the Robert A. Welch Foundation and J.M.C. was supported by a Postdoctoral Fellowship (GM12059) from the National Institutes of Health. Alanosine was kindly provided by the Drug Synthesis and Chemistry Branch, and 2{\textquoteright}-deoxycoformycin by the Natural Products Branch, of the Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute. We are also grateful to the Parke-Davis Pharmaceutical Research Division of the Warner-Lambert Co. providing 2{\textquoteright}-deoxycoformycin (Pentostatin).",
year = "1990",
month = aug,
doi = "10.1016/0888-7543(90)90189-2",
language = "English (US)",
volume = "7",
pages = "476--485",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "4",
}