TY - JOUR
T1 - Striatal antibodies in children with Tourette's syndrome
T2 - Multivariate discriminant analysis of IgG repertoires
AU - Wendlandt, John T.
AU - Grus, Franz H.
AU - Hansen, Bendt H.
AU - Singer, Harvey S.
N1 - Funding Information:
The authors wish to thank Dr. Pamela Talalay for helpful discussion during the preparation of the manuscript. Our research was supported by grants from the National Institutes of Health (N537706) and the National Tourette's Syndrome Association.
PY - 2001/9/3
Y1 - 2001/9/3
N2 - Antineuronal antibodies have been postulated to be the underlying pathophysiology in TS and other neuropsychiatric disorders. Serum antibodies from 20 children with TS, and 21 control subjects against human striatum, globus pallidus, muscle, and HTB-10 cells were assayed by Western blot techniques. A MANOVA differentiated between TS and control blots, and a discriminant analysis demonstrated which variables contributed most to differences between groups. Prominent differences between TS and control blots were identified using striatal epitopes in contrast to similar patterns shown between groups for globus pallidus, muscle and HTB-10 tissue, supporting striatal autoimmune involvement in TS pathophysiology.
AB - Antineuronal antibodies have been postulated to be the underlying pathophysiology in TS and other neuropsychiatric disorders. Serum antibodies from 20 children with TS, and 21 control subjects against human striatum, globus pallidus, muscle, and HTB-10 cells were assayed by Western blot techniques. A MANOVA differentiated between TS and control blots, and a discriminant analysis demonstrated which variables contributed most to differences between groups. Prominent differences between TS and control blots were identified using striatal epitopes in contrast to similar patterns shown between groups for globus pallidus, muscle and HTB-10 tissue, supporting striatal autoimmune involvement in TS pathophysiology.
KW - Antineuronal antibodies
KW - Discriminant analysis
KW - IgG repertoire
KW - Tourette's syndrome
KW - Western blot
UR - http://www.scopus.com/inward/record.url?scp=0035801730&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035801730&partnerID=8YFLogxK
U2 - 10.1016/S0165-5728(01)00370-8
DO - 10.1016/S0165-5728(01)00370-8
M3 - Article
C2 - 11525807
AN - SCOPUS:0035801730
SN - 0165-5728
VL - 119
SP - 106
EP - 113
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1
ER -