Stressing the role of O-GlcNAc: Linking cell survival to keratin modification

Jeremy D. Rotty; Gerald W. Hart; Pierre A. Coulombe

doi:10.1038/ncb0910-847

Stressing the role of O-GlcNAc: Linking cell survival to keratin modification

Jeremy D. Rotty, Gerald W. Hart, Pierre A. Coulombe

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Mounting evidence suggests that keratin post-translational modifications are crucial for many cellular processes. Now, keratin 18 modified by the addition of an O-linked N-acetylglucosamine residue is shown to be as a critical effector of stress-responsive Akt signalling, providing an important link between keratin glycosylation and cell survival.

Original language	English (US)
Pages (from-to)	847-849
Number of pages	3
Journal	Nature cell biology
Volume	12
Issue number	9
DOIs	https://doi.org/10.1038/ncb0910-847
State	Published - Sep 2010

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb0910-847

Cite this

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title = "Stressing the role of O-GlcNAc: Linking cell survival to keratin modification",

abstract = "Mounting evidence suggests that keratin post-translational modifications are crucial for many cellular processes. Now, keratin 18 modified by the addition of an O-linked N-acetylglucosamine residue is shown to be as a critical effector of stress-responsive Akt signalling, providing an important link between keratin glycosylation and cell survival.",

author = "Rotty, {Jeremy D.} and Hart, {Gerald W.} and Coulombe, {Pierre A.}",

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AB - Mounting evidence suggests that keratin post-translational modifications are crucial for many cellular processes. Now, keratin 18 modified by the addition of an O-linked N-acetylglucosamine residue is shown to be as a critical effector of stress-responsive Akt signalling, providing an important link between keratin glycosylation and cell survival.

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Stressing the role of O-GlcNAc: Linking cell survival to keratin modification

Abstract

ASJC Scopus subject areas

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