Stress-induced plasticity of monoamine axons

Ying Liu, Shoji Nakamura

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Central serotonergic (5-HT) and noradrenergic (NA) neurons, which innervate the same regions of the brain, are known to play a crucial role in emotion and mood. These monoamine neurons have a great capacity to alter axonal morphology in response to repeated stress. The morphological responses of 5-HT and NA axons to repeated stress are different, and they sometimes even demonstrate opposite responses (namely, either sprouting or degeneration). Moreover, a morphological interaction also occurs between 5-HT and NA axons during axonal regeneration. This review describes the differential features of axonal plasticity of 5-HT and NA neurons in relation to stress, and discusses the possible roles that the morphological plasticity of 5-HT and NA axons may play in the pathophysiology of depression.

Original languageEnglish (US)
Pages (from-to)1794-1801
Number of pages8
JournalFrontiers in Bioscience
Issue number2 P.1591-2006
StatePublished - 2006


  • Depression
  • Neuroplasticity
  • Noradrenaline
  • Serotonin
  • Stress
  • Yamaguchi 755-8505

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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