TY - CHAP
T1 - Strategies to Modulate the Blood-Brain Barrier for Directed Brain Tumor Targeting
AU - Schiapparelli, Paula
AU - Lara-Velazquez, Montserrat
AU - Al-kharboosh, Rawan
AU - Su, Hao
AU - Cui, Honggang
AU - Quinones-Hinojosa, Alfredo
N1 - Publisher Copyright:
© 2021, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021
Y1 - 2021
N2 - Glioblastoma (GBM) is the most common and aggressive primary brain tumors in adults. Despite being one of the most genetically and molecularly characterized tumors, patient prognosis remains dismal. Many factors have contributed to the challenges of developing effective clinical therapies, such as tumor heterogeneity, immune-suppressive microenvironment, and therapy resistance. From the perspective of therapeutics delivery, one of the main obstacles is to get newly discovered therapeutic agents across the blood-brain barrier (BBB) to penetrate the brain parenchyma. In this context, this book chapter provides an overview of three different strategies of delivering antitumor agents intended to circumvent the BBB and highlight the strengths and weakness of each approach.
AB - Glioblastoma (GBM) is the most common and aggressive primary brain tumors in adults. Despite being one of the most genetically and molecularly characterized tumors, patient prognosis remains dismal. Many factors have contributed to the challenges of developing effective clinical therapies, such as tumor heterogeneity, immune-suppressive microenvironment, and therapy resistance. From the perspective of therapeutics delivery, one of the main obstacles is to get newly discovered therapeutic agents across the blood-brain barrier (BBB) to penetrate the brain parenchyma. In this context, this book chapter provides an overview of three different strategies of delivering antitumor agents intended to circumvent the BBB and highlight the strengths and weakness of each approach.
KW - BBB permeability
KW - Blood-brain barrier
KW - Brain drug delivery
KW - Convection-enhanced delivery (CED)
KW - Focused ultrasound (FUS)
KW - Glioma
KW - Supramolecular hydrogels
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U2 - 10.1007/978-1-0716-1052-7_3
DO - 10.1007/978-1-0716-1052-7_3
M3 - Chapter
AN - SCOPUS:85097149734
T3 - Neuromethods
SP - 79
EP - 108
BT - Neuromethods
PB - Humana Press Inc.
ER -