Strategies for local gene therapy of corneal allograft rejection

Pho Nguyen; Samuel C. Yiu

doi:10.4103/0974-9233.106382

Strategies for local gene therapy of corneal allograft rejection

Pho Nguyen, Samuel C. Yiu

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Penetrating keratoplasty is the most common type of tissue transplant in humans. Irreversible immune rejection leads to loss of vision and graft failure. This complex immune response further predisposes future corneal transplants to rejection and failure. A diverse armamentarium of surgical and pharmacologic tools is available to improve graft survival. In this review, we will discuss the various gene therapeutic strategies aimed at potentiating the anterior chamber-associated immune deviation to extend graft survival.

Original language	English (US)
Pages (from-to)	11-25
Number of pages	15
Journal	Middle East African Journal of Ophthalmology
Volume	20
Issue number	1
DOIs	https://doi.org/10.4103/0974-9233.106382
State	Published - Jan 2013

Keywords

Adenovirus
Corneal Transplant
Dendrimer
Gene Therapy
Immune Privilege
Neovascularization
Plasmid
Rejection

ASJC Scopus subject areas

Ophthalmology

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10.4103/0974-9233.106382

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AB - Penetrating keratoplasty is the most common type of tissue transplant in humans. Irreversible immune rejection leads to loss of vision and graft failure. This complex immune response further predisposes future corneal transplants to rejection and failure. A diverse armamentarium of surgical and pharmacologic tools is available to improve graft survival. In this review, we will discuss the various gene therapeutic strategies aimed at potentiating the anterior chamber-associated immune deviation to extend graft survival.

KW - Adenovirus

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KW - Immune Privilege

KW - Neovascularization

KW - Plasmid

KW - Rejection

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Strategies for local gene therapy of corneal allograft rejection

Abstract

Keywords

ASJC Scopus subject areas

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