TY - JOUR
T1 - Strategies for Heating Up Cold Tumors to Boost Immunotherapies
AU - Zabransky, Daniel J.
AU - Yarchoan, Mark
AU - Jaffee, Elizabeth M.
N1 - Funding Information:
D.J.Z. is supported by grant 5T32CA009071-39, Conquer Cancer Foundation Young Investigator Award, and the Cholangiocarcinoma Foundation Research Fellowship.
Publisher Copyright:
© 2023 Annual Reviews Inc.. All rights reserved.
PY - 2023/4/11
Y1 - 2023/4/11
N2 - Immune checkpoint inhibitors induce significant and durable treatment responses in about 20% of all cancers, but many patients have natural resistance to current immunotherapies. The past decade of technological advances has resulted in large-scale profiling of many cancers and their tumor microenvironments, rapidly expanding our understanding of the mechanisms utilized by tumors to create immune-resistant microenvironments. In this review, we discuss key factors that create immune resistance and emerging concepts that are redefining how we view immune resistance, as well as highlight novel strategies that aim to convert immune-resistant into immune-sensitive tumors.
AB - Immune checkpoint inhibitors induce significant and durable treatment responses in about 20% of all cancers, but many patients have natural resistance to current immunotherapies. The past decade of technological advances has resulted in large-scale profiling of many cancers and their tumor microenvironments, rapidly expanding our understanding of the mechanisms utilized by tumors to create immune-resistant microenvironments. In this review, we discuss key factors that create immune resistance and emerging concepts that are redefining how we view immune resistance, as well as highlight novel strategies that aim to convert immune-resistant into immune-sensitive tumors.
KW - clinical trials
KW - immune checkpoint inhibitors
KW - immunotherapy
KW - tumor microenvironment
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U2 - 10.1146/annurev-cancerbio-061421-040258
DO - 10.1146/annurev-cancerbio-061421-040258
M3 - Review article
AN - SCOPUS:85153950255
SN - 2472-3428
VL - 7
SP - 149
EP - 170
JO - Annual Review of Cancer Biology
JF - Annual Review of Cancer Biology
ER -