Strategies for Heating Up Cold Tumors to Boost Immunotherapies

Daniel J. Zabransky; Mark Yarchoan; Elizabeth M. Jaffee

doi:10.1146/annurev-cancerbio-061421-040258

Strategies for Heating Up Cold Tumors to Boost Immunotherapies

Daniel J. Zabransky, Mark Yarchoan, Elizabeth M. Jaffee

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Immune checkpoint inhibitors induce significant and durable treatment responses in about 20% of all cancers, but many patients have natural resistance to current immunotherapies. The past decade of technological advances has resulted in large-scale profiling of many cancers and their tumor microenvironments, rapidly expanding our understanding of the mechanisms utilized by tumors to create immune-resistant microenvironments. In this review, we discuss key factors that create immune resistance and emerging concepts that are redefining how we view immune resistance, as well as highlight novel strategies that aim to convert immune-resistant into immune-sensitive tumors.

Original language	English (US)
Pages (from-to)	149-170
Number of pages	22
Journal	Annual Review of Cancer Biology
Volume	7
DOIs	https://doi.org/10.1146/annurev-cancerbio-061421-040258
State	Published - Apr 11 2023

Keywords

clinical trials
immune checkpoint inhibitors
immunotherapy
tumor microenvironment

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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10.1146/annurev-cancerbio-061421-040258

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title = "Strategies for Heating Up Cold Tumors to Boost Immunotherapies",

abstract = "Immune checkpoint inhibitors induce significant and durable treatment responses in about 20% of all cancers, but many patients have natural resistance to current immunotherapies. The past decade of technological advances has resulted in large-scale profiling of many cancers and their tumor microenvironments, rapidly expanding our understanding of the mechanisms utilized by tumors to create immune-resistant microenvironments. In this review, we discuss key factors that create immune resistance and emerging concepts that are redefining how we view immune resistance, as well as highlight novel strategies that aim to convert immune-resistant into immune-sensitive tumors.",

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AU - Yarchoan, Mark

AU - Jaffee, Elizabeth M.

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Y1 - 2023/4/11

N2 - Immune checkpoint inhibitors induce significant and durable treatment responses in about 20% of all cancers, but many patients have natural resistance to current immunotherapies. The past decade of technological advances has resulted in large-scale profiling of many cancers and their tumor microenvironments, rapidly expanding our understanding of the mechanisms utilized by tumors to create immune-resistant microenvironments. In this review, we discuss key factors that create immune resistance and emerging concepts that are redefining how we view immune resistance, as well as highlight novel strategies that aim to convert immune-resistant into immune-sensitive tumors.

AB - Immune checkpoint inhibitors induce significant and durable treatment responses in about 20% of all cancers, but many patients have natural resistance to current immunotherapies. The past decade of technological advances has resulted in large-scale profiling of many cancers and their tumor microenvironments, rapidly expanding our understanding of the mechanisms utilized by tumors to create immune-resistant microenvironments. In this review, we discuss key factors that create immune resistance and emerging concepts that are redefining how we view immune resistance, as well as highlight novel strategies that aim to convert immune-resistant into immune-sensitive tumors.

KW - clinical trials

KW - immune checkpoint inhibitors

KW - immunotherapy

KW - tumor microenvironment

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DO - 10.1146/annurev-cancerbio-061421-040258

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AN - SCOPUS:85153950255

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VL - 7

SP - 149

EP - 170

JO - Annual Review of Cancer Biology

JF - Annual Review of Cancer Biology

ER -

Strategies for Heating Up Cold Tumors to Boost Immunotherapies

Abstract

Keywords

ASJC Scopus subject areas

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