TY - JOUR
T1 - Strain-Encoded Cardiac MR During High-Dose Dobutamine Stress Testing
T2 - Comparison to Cine Imaging and to Myocardial Tagging
AU - Korosoglou, Grigorios
AU - Futterer, Simon
AU - Humpert, Per M.
AU - Riedle, Nina
AU - Lossnitzer, Dirk
AU - Hoerig, Birgit
AU - Steen, Henning
AU - Giannitsis, Evangelos
AU - Osman, Nael F.
AU - Katus, Hugo A.
PY - 2009/5
Y1 - 2009/5
N2 - Purpose: To investigate regional strain response during high-dose dobutamine stress cardiac magnetic resonance imaging (DS-CMR) using myocardial tagging and Strain- Encoded MR (SENC). Materials and Methods: Stress induced ischemia was as- sessed by wall motion analysis, by tagged CMR and by SENC in 65 patients with suspected or known CAD who underwent DS-CMR in a clinical 1.5 Tesla scanner. Coronary angiogra- phy deemed as the standard reference for the presence or absence of CAD (50% diameter stenosis) in all patients. Results: SENC and conventional tagging detected abnor- mal strain response in six and five additional patients, respectively, who were missed by cine images and proved to have CAD by angiography (P 0.05 for SENC versus cine, P 0.06 for tagging versus cine and p NS for SENC versus tagging). On a per-vessel level, wall motion analysis on cine images showed high specificity (95%) but moderate sensitivity (70%) for the detection of CAD. Tagging and SENC yielded significantly higher sensitivity of 81% and 89%, respectively (P 0.05 for tagging and P 0.01 for SENC versus wall motion analysis, and p NS for SENC versus tagging), while specificity was equally high (96% and 94%, respectively, P NS for all). Conclusion: Both the direct color-coded visualization of strain on CMR images and the generation of additional visual markers within the myocardium with tagged CMR represent useful adjuncts for DS-CMR, which may provide incremental value for the detection of CAD in humans.
AB - Purpose: To investigate regional strain response during high-dose dobutamine stress cardiac magnetic resonance imaging (DS-CMR) using myocardial tagging and Strain- Encoded MR (SENC). Materials and Methods: Stress induced ischemia was as- sessed by wall motion analysis, by tagged CMR and by SENC in 65 patients with suspected or known CAD who underwent DS-CMR in a clinical 1.5 Tesla scanner. Coronary angiogra- phy deemed as the standard reference for the presence or absence of CAD (50% diameter stenosis) in all patients. Results: SENC and conventional tagging detected abnor- mal strain response in six and five additional patients, respectively, who were missed by cine images and proved to have CAD by angiography (P 0.05 for SENC versus cine, P 0.06 for tagging versus cine and p NS for SENC versus tagging). On a per-vessel level, wall motion analysis on cine images showed high specificity (95%) but moderate sensitivity (70%) for the detection of CAD. Tagging and SENC yielded significantly higher sensitivity of 81% and 89%, respectively (P 0.05 for tagging and P 0.01 for SENC versus wall motion analysis, and p NS for SENC versus tagging), while specificity was equally high (96% and 94%, respectively, P NS for all). Conclusion: Both the direct color-coded visualization of strain on CMR images and the generation of additional visual markers within the myocardium with tagged CMR represent useful adjuncts for DS-CMR, which may provide incremental value for the detection of CAD in humans.
KW - Dobutamine stress
KW - Inducible ischemia
KW - Myocardial strain response
KW - Strain-Encoded MR
KW - tagged CMR
UR - http://www.scopus.com/inward/record.url?scp=66149132678&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66149132678&partnerID=8YFLogxK
U2 - 10.1002/jmri.21759
DO - 10.1002/jmri.21759
M3 - Article
C2 - 19388131
AN - SCOPUS:66149132678
SN - 1053-1807
VL - 29
SP - 1053
EP - 1061
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 5
ER -