Stochastic Modelling of Multiple Random Genetic Mutations Under the Cancer Stem Cell Hypothesis

Cristian Tomasetti

doi:10.1080/08898480.2012.725379

Stochastic Modelling of Multiple Random Genetic Mutations Under the Cancer Stem Cell Hypothesis

Cristian Tomasetti

Research output: Contribution to journal › Article › peer-review

Abstract

The probability distribution for the size of each of the various cancer cell subpopulations created by random genetic mutations is expressed in the case of non-exponential growth of cancer and in the case of a heterogeneous tumor cell population.

Original language	English (US)
Pages (from-to)	200-213
Number of pages	14
Journal	Mathematical Population Studies
Volume	19
Issue number	4
DOIs	https://doi.org/10.1080/08898480.2012.725379
State	Published - Oct 2012
Externally published	Yes

Keywords

branching processes
genetic mutations
stem cells
tumor growth
tumor heterogeneity

ASJC Scopus subject areas

Demography
Geography, Planning and Development
Agricultural and Biological Sciences(all)

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10.1080/08898480.2012.725379

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title = "Stochastic Modelling of Multiple Random Genetic Mutations Under the Cancer Stem Cell Hypothesis",

abstract = "The probability distribution for the size of each of the various cancer cell subpopulations created by random genetic mutations is expressed in the case of non-exponential growth of cancer and in the case of a heterogeneous tumor cell population.",

keywords = "branching processes, genetic mutations, stem cells, tumor growth, tumor heterogeneity",

author = "Cristian Tomasetti",

note = "Funding Information: The author thanks Prof. Giovanni Parmigiani for his support and encouragement. The author{\textquoteright}s work was supported in part by the National Institute of Health under Grant T32 CA009337.",

year = "2012",

month = oct,

doi = "10.1080/08898480.2012.725379",

language = "English (US)",

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AU - Tomasetti, Cristian

N1 - Funding Information: The author thanks Prof. Giovanni Parmigiani for his support and encouragement. The author’s work was supported in part by the National Institute of Health under Grant T32 CA009337.

PY - 2012/10

Y1 - 2012/10

N2 - The probability distribution for the size of each of the various cancer cell subpopulations created by random genetic mutations is expressed in the case of non-exponential growth of cancer and in the case of a heterogeneous tumor cell population.

AB - The probability distribution for the size of each of the various cancer cell subpopulations created by random genetic mutations is expressed in the case of non-exponential growth of cancer and in the case of a heterogeneous tumor cell population.

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KW - genetic mutations

KW - stem cells

KW - tumor growth

KW - tumor heterogeneity

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JO - Mathematical Population Studies

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Stochastic Modelling of Multiple Random Genetic Mutations Under the Cancer Stem Cell Hypothesis

Abstract

Keywords

ASJC Scopus subject areas

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