Stimulated single‐fiber electromyography in lambert‐eaton myasthenic syndrome

Vinay Chaudhry, Danny F. Watson, Shawn J. Bird, David R. Cornblath

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The Lambert‐Eaton myasthenic syndrome (LEMS) is an autoimmune disorder of neuromuscular transmission. Electrodiagnosis is confirmed by an increase in compound muscle action potential amplitude during high‐frequency repetitive nerve stimulation or following brief exercise. We describe the results of stimulated single‐fiber electromyography in 4 patients with disorders of neuromuscular transmission: LEMS (2), LEMS/myasthenia gravis (MG) overlap (1), and MG (1). Stimulated SFEMG was performed in the extensor digitorum communis muscle with axonal intramuscular suprathreshold stimulation at low and high rates. In all 4 patients, a rate dependence of jitter was found. In LEMS and LEMS/MG, jitter and blocking improved with high stimulation rates, as compared with the opposite effect in MG. We conclude that stimulated SFEMG is a valuable technique in the diagnosis of LEMS.

Original languageEnglish (US)
Pages (from-to)1227-1230
Number of pages4
JournalMuscle & nerve
Issue number12
StatePublished - Dec 1991


  • Lambert‐Eaton myasthenic syndrome
  • jitter
  • myasthenia gravis
  • single fiber electromyography

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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