TY - JOUR
T1 - Stillbirths
T2 - Rates, risk factors, and acceleration towards 2030
AU - Lancet Ending Preventable Stillbirths Series study group
AU - Lancet Stillbirth Epidemiology investigator group
AU - Lawn, Joy E.
AU - Blencowe, Hannah
AU - Waiswa, Peter
AU - Amouzou, Agbessi
AU - Mathers, Colin
AU - Hogan, Dan
AU - Flenady, Vicki
AU - Frøen, J. Frederik
AU - Qureshi, Zeshan U.
AU - Calderwood, Claire
AU - Shiekh, Suhail
AU - Jassir, Fiorella Bianchi
AU - You, Danzhen
AU - McClure, Elizabeth M.
AU - Mathai, Matthews
AU - Cousens, Simon
AU - Kinney, Mary V.
AU - De Bernis, Luc
AU - Heazell, Alexander
AU - Leisher, Susannah Hopkins
AU - Azad, Kishwar
AU - Rahman, Anisur
AU - El-Arifeen, Shams
AU - Day, Louise T.
AU - Saha, Stacy L.
AU - Alam, Shafiul
AU - Wangdi, Sonam
AU - Ilboudo, Tinga Fulbert
AU - Zhu, Jun
AU - Liang, Juan
AU - Mu, Yi
AU - Li, Xiaohong
AU - Zhong, Nanbert
AU - Kyprianou, Theopisti
AU - Allvee, Kärt
AU - Gissler, Mika
AU - Zeitlin, Jennifer
AU - Bah, Abdouli
AU - Jawara, Lamin
AU - Lack, Nicholas
AU - De Maria Herandez, Flor
AU - More, Neena Shah
AU - Nair, Nirmala
AU - Tripathy, Prasanta
AU - Kumar, Rajesh
AU - Newtonraj, Ariarathinam
AU - Kaur, Manmeet
AU - Gupta, Madhu
AU - Varghese, Beena
AU - Isakova, Jelena
N1 - Funding Information:
We thank the staff of the General Bureau of Statistics of Suriname, Malaysian National Statistical Office, Central Informatics Organisation of Bahrain, Turkish Statistical Institute, National Statistical Committee Belarus, Instituto Nacional de Estadística y Geografía (Mexico), Instituto Nacional de Estadística y Censos (Costa Rica), and Instituto Nacional de Estadísticas (Chile) for their assistance in responding to queries in their country's stillbirth rate data. We thank Josh Vogel and the WHO Multicountry Survey on Maternal and Newborn Health Research Network for their assistance in reanalysing the stillbirth rate data from the WHO Global Survey on Maternal and Perinatal Health and the WHO Multi-country Survey on Maternal and Newborn Health. No specific funding was received for the Lancet Ending preventable stillbirths Series but the time of HB and JEL for the stillbirth rate estimates was funded by the Bill & Melinda Gates Foundation through Save the Children's Saving Newborn Lives programme. JFF was funded in part by a technical support grant from the Norwegian Agency for Development Cooperation and by the Centre for Intervention Science in Maternal and Child Health (project number 223269 ), which is funded by the Research Council of Norway through its Centers of Excellence scheme and the University of Bergen, Norway . The funders had no role in the study design, data collection, data analysis, data interpretation, or writing of the Series.
Funding Information:
We thank the staff of the General Bureau of Statistics of Suriname, Malaysian National Statistical Offi ce, Central Informatics Organisation of Bahrain, Turkish Statistical Institute, National Statistical Committee Belarus, Instituto Nacional de Estadística y Geografía (Mexico), Instituto Nacional de Estadística y Censos (Costa Rica), and Instituto Nacional de Estadísticas (Chile) for their assistance in responding to queries in their country’s stillbirth rate data. We thank Josh Vogel and the WHO Multicountry Survey on Maternal and Newborn Health Research Network for their assistance in reanalysing the stillbirth rate data from the WHO Global Survey on Maternal and Perinatal Health and the WHO Multi-country Survey on Maternal and Newborn Health. No specifi c funding was received for the Lancet Ending preventable stillbirths Series but the time of HB and JEL for the stillbirth rate estimates was funded by the Bill & Melinda Gates Foundation through Save the Children’s Saving Newborn Lives programme. JFF was funded in part by a technical support grant from the Norwegian Agency for Development Cooperation and by the Centre for Intervention Science in Maternal and Child Health (project number 223269), which is funded by the Research Council of Norway through its Centers of Excellence scheme and the University of Bergen, Norway. The funders had no role in the study design, data collection, data analysis, data interpretation, or writing of the Series.
Funding Information:
Bangladesh Kishwar Azad (Diabetic Association of Bangladesh Perinatal Care Project, Dhaka), Anisur Rahman, Shams El-Arifeen (International Centre for Diarrhoeal Disease Research, Dhaka), Louise T Day, Stacy L Saha, Shafiul Alam (LAMB Integrated Rural Health and Development, Dinajpur); Bhutan Sonam Wangdi (Ministry of Health, Thimphu); Burkina Faso Tinga Fulbert Ilboudo (District Health Information System 2, Ouagadougou); China Jun Zhu, Juan Liang, Yi Mu, Xiaohong Li (West China Second University Hospital, Sichuan), Nanbert Zhong (Peking University Center of Medical Genetics, Beijing); Cyprus Theopisti Kyprianou (Ministry of Health, Nicosia); Estonia Kärt Allvee (Estonian Birth and Abortion Registries, Tallinn); Finland Mika Gissler (National Institute for Health and Welfare, Helsinki); France Jennifer Zeitlin (INSERM [EURO-PERISTAT], Paris); Gambia Abdouli Bah, Lamin Jawara (Health Management Information System, Banjul); Ghana Peter Waiswa (INDEPTH network, Maternal and Newborn Working Group, Accra); Germany Nicholas Lack (Bavarian Institute for Quality Assurance, Munich); Guatemala Flor de Maria Herandez (Instituto Nacional de Estadistica, Guatemala City); India Neena Shah More (Society for Nutrition, Education and Health Action, Mumbai), Nirmala Nair, Prasanta Tripathy (Ekjut, Jharkhand/Orissa), Rajesh Kumar, Ariarathinam Newtonraj, Manmeet Kaur, Madhu Gupta (Post Graduate Institute of Medical Education and Research, Chandigarh), Beena Varghese (Public Health Foundation of India, New Delhi); Lithuania Jelena Isakova (Institute of Hygiene, Vilnius), Malawi Tambosi Phiri, Jennifer A Hall (MaiMwana, Mchinji); Moldova Ala Curteanu (Mother and Child Institute, Chisinau); Nepal Dharma Manandhar (Mother and Infant Research Association, Kathmandu); Netherlands Chantal Hukkelhoven, Joyce Dijs-Elsinga (Perined, Utrecht); Norway Kari Klungsøyr (Norwegian Institute of Public Health, Oslo), Olva Poppe (Univesity of Oslo, Oslo); Portugal Henrique Barros, Sofia Correia (EPIUnit, Institute of Public Health, University of Porto, Porto); Georgia Shorena Tsiklauri (GEOSTAT, Tbilisi); Slovakia Jan Cap, Zuzana Podmanicka (Statistics Slovakia, Bratislava); Poland Katarzyna Szamotulska (Institute of Mother and Child, Warsaw); South Africa Robert Pattison (South African Medical Research Council, Cape Town); Sudan Ahmed Ali Hassan (Sudan Stillbirth Society, Khartoum); Sweden Aimable Musafili (Uppsala University, Uppsala), Sanni Kujala (Karolinska Institute, Solna), Anna Bergstrom (Uppsala University, Uppsala), Jens Langhoff-Roos (University of Copenhagen, Copenhagen), Ellen Lundqvist (National Board of Health and Welfare, Stockholm); Uganda Daniel Kadobera (Makerere University Iganga, Iganga); UK Anthony Costello, Tim Colbourn, Edward Fottrell, Audrey Prost, David Osrin, Carina King, Melissa Neuman (University College London, London), Jane Hirst (University of Oxford, Oxford), Sayed Rubayet (Save the Children, London), Vicki Flenady (Mater University, Dublin), Lucy Smith, Bradley N Manktelow, Elizabeth S Draper (University of Leicester, MBRRACE-UK, Leicester).
Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/2/6
Y1 - 2016/2/6
N2 - An estimated 2·6 million third trimester stillbirths occurred in 2015 (uncertainty range 2·4-3·0 million). The number of stillbirths has reduced more slowly than has maternal mortality or mortality in children younger than 5 years, which were explicitly targeted in the Millennium Development Goals. The Every Newborn Action Plan has the target of 12 or fewer stillbirths per 1000 births in every country by 2030. 94 mainly high-income countries and upper middle-income countries have already met this target, although with noticeable disparities. At least 56 countries, particularly in Africa and in areas aff ected by confl ict, will have to more than double present progress to reach this target. Most (98%) stillbirths are in low-income and middle-income countries. Improved care at birth is essential to prevent 1·3 million (uncertainty range 1·2-1·6 million) intrapartum stillbirths, end preventable maternal and neonatal deaths, and improve child development. Estimates for stillbirth causation are impeded by various classifi cation systems, but for 18 countries with reliable data, congenital abnormalities account for a median of only 7·4% of stillbirths. Many disorders associated with stillbirths are potentially modifi able and often coexist, such as maternal infections (population attributable fraction: malaria 8·0% and syphilis 7·7%), non-communicable diseases, nutrition and lifestyle factors (each about 10%), and maternal age older than 35 years (6·7%). Prolonged pregnancies contribute to 14·0% of stillbirths. Causal pathways for stillbirth frequently involve impaired placental function, either with fetal growth restriction or preterm labour, or both. Two-thirds of newborns have their births registered. However, less than 5% of neonatal deaths and even fewer stillbirths have death registration. Records and registrations of all births, stillbirths, neonatal, and maternal deaths in a health facility would substantially increase data availability. Improved data alone will not save lives but provide a way to target interventions to reach more than 7000 women every day worldwide who experience the reality of stillbirth.
AB - An estimated 2·6 million third trimester stillbirths occurred in 2015 (uncertainty range 2·4-3·0 million). The number of stillbirths has reduced more slowly than has maternal mortality or mortality in children younger than 5 years, which were explicitly targeted in the Millennium Development Goals. The Every Newborn Action Plan has the target of 12 or fewer stillbirths per 1000 births in every country by 2030. 94 mainly high-income countries and upper middle-income countries have already met this target, although with noticeable disparities. At least 56 countries, particularly in Africa and in areas aff ected by confl ict, will have to more than double present progress to reach this target. Most (98%) stillbirths are in low-income and middle-income countries. Improved care at birth is essential to prevent 1·3 million (uncertainty range 1·2-1·6 million) intrapartum stillbirths, end preventable maternal and neonatal deaths, and improve child development. Estimates for stillbirth causation are impeded by various classifi cation systems, but for 18 countries with reliable data, congenital abnormalities account for a median of only 7·4% of stillbirths. Many disorders associated with stillbirths are potentially modifi able and often coexist, such as maternal infections (population attributable fraction: malaria 8·0% and syphilis 7·7%), non-communicable diseases, nutrition and lifestyle factors (each about 10%), and maternal age older than 35 years (6·7%). Prolonged pregnancies contribute to 14·0% of stillbirths. Causal pathways for stillbirth frequently involve impaired placental function, either with fetal growth restriction or preterm labour, or both. Two-thirds of newborns have their births registered. However, less than 5% of neonatal deaths and even fewer stillbirths have death registration. Records and registrations of all births, stillbirths, neonatal, and maternal deaths in a health facility would substantially increase data availability. Improved data alone will not save lives but provide a way to target interventions to reach more than 7000 women every day worldwide who experience the reality of stillbirth.
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U2 - 10.1016/S0140-6736(15)00837-5
DO - 10.1016/S0140-6736(15)00837-5
M3 - Review article
C2 - 26794078
AN - SCOPUS:84959527417
SN - 0140-6736
VL - 387
SP - 587
EP - 603
JO - The Lancet
JF - The Lancet
IS - 10018
ER -