Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary

Elizabeth T. Ables; Daniela Drummond-Barbosa

doi:10.1007/s40778-017-0070-z

Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary

Elizabeth T. Ables, Daniela Drummond-Barbosa

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Purpose of Review: Stem cells respond to local paracrine signals; more recently, however, systemic hormones have also emerged as key regulators of stem cells. This review explores the role of steroid hormones in stem cells, using the Drosophila germline stem cell as a centerpiece for discussion. Recent Findings: Stem cells sense and respond directly and indirectly to steroid hormones, which regulate diverse sets of target genes via interactions with nuclear hormone receptors. Hormone-regulated networks likely integrate the actions of multiple systemic signals to adjust the activity of stem cell lineages in response to changes in physiological status. Summary: Hormones are inextricably linked to animal physiology and can control stem cells and their local niches. Elucidating the molecular mechanisms of hormone signaling in stem cells is essential for our understanding of the fundamental underpinnings of stem cell biology and for informing new therapeutic interventions against cancers or for regenerative medicine.

Original language	English (US)
Pages (from-to)	9-18
Number of pages	10
Journal	Current Stem Cell Reports
Volume	3
Issue number	1
DOIs	https://doi.org/10.1007/s40778-017-0070-z
State	Published - Mar 1 2017

Keywords

Cell fate
Differentiation
Ecdysone
Germ cells
Germline
Nuclear hormone receptor
Oocyte
Oogenesis
Self-renewal

ASJC Scopus subject areas

Molecular Biology
Genetics
Developmental Biology
Cell Biology

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10.1007/s40778-017-0070-z

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title = "Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary",

abstract = "Purpose of Review: Stem cells respond to local paracrine signals; more recently, however, systemic hormones have also emerged as key regulators of stem cells. This review explores the role of steroid hormones in stem cells, using the Drosophila germline stem cell as a centerpiece for discussion. Recent Findings: Stem cells sense and respond directly and indirectly to steroid hormones, which regulate diverse sets of target genes via interactions with nuclear hormone receptors. Hormone-regulated networks likely integrate the actions of multiple systemic signals to adjust the activity of stem cell lineages in response to changes in physiological status. Summary: Hormones are inextricably linked to animal physiology and can control stem cells and their local niches. Elucidating the molecular mechanisms of hormone signaling in stem cells is essential for our understanding of the fundamental underpinnings of stem cell biology and for informing new therapeutic interventions against cancers or for regenerative medicine.",

keywords = "Cell fate, Differentiation, Ecdysone, Germ cells, Germline, Nuclear hormone receptor, Oocyte, Oogenesis, Self-renewal",

author = "Ables, {Elizabeth T.} and Daniela Drummond-Barbosa",

note = "Funding Information: We apologize to our colleagues whose original work could not be cited due to space limitations. Many thanks to Danielle Finger for the assistance with the figure preparation and to Lesley Weaver and members of the Ables laboratory for critical reading of this review. Work from our laboratories is supported by National Institutes of Health (NIH) R01 GM069875 (D.D.-B.), NIH R15 GM117502 (E.T.A.), and March of Dimes Basil O'Connor Research Starter Award 5-FY14-62 (E.T.A.). Publisher Copyright: {\textcopyright} 2017, Springer International Publishing AG.",

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doi = "10.1007/s40778-017-0070-z",

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AU - Ables, Elizabeth T.

AU - Drummond-Barbosa, Daniela

N1 - Funding Information: We apologize to our colleagues whose original work could not be cited due to space limitations. Many thanks to Danielle Finger for the assistance with the figure preparation and to Lesley Weaver and members of the Ables laboratory for critical reading of this review. Work from our laboratories is supported by National Institutes of Health (NIH) R01 GM069875 (D.D.-B.), NIH R15 GM117502 (E.T.A.), and March of Dimes Basil O'Connor Research Starter Award 5-FY14-62 (E.T.A.). Publisher Copyright: © 2017, Springer International Publishing AG.

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N2 - Purpose of Review: Stem cells respond to local paracrine signals; more recently, however, systemic hormones have also emerged as key regulators of stem cells. This review explores the role of steroid hormones in stem cells, using the Drosophila germline stem cell as a centerpiece for discussion. Recent Findings: Stem cells sense and respond directly and indirectly to steroid hormones, which regulate diverse sets of target genes via interactions with nuclear hormone receptors. Hormone-regulated networks likely integrate the actions of multiple systemic signals to adjust the activity of stem cell lineages in response to changes in physiological status. Summary: Hormones are inextricably linked to animal physiology and can control stem cells and their local niches. Elucidating the molecular mechanisms of hormone signaling in stem cells is essential for our understanding of the fundamental underpinnings of stem cell biology and for informing new therapeutic interventions against cancers or for regenerative medicine.

AB - Purpose of Review: Stem cells respond to local paracrine signals; more recently, however, systemic hormones have also emerged as key regulators of stem cells. This review explores the role of steroid hormones in stem cells, using the Drosophila germline stem cell as a centerpiece for discussion. Recent Findings: Stem cells sense and respond directly and indirectly to steroid hormones, which regulate diverse sets of target genes via interactions with nuclear hormone receptors. Hormone-regulated networks likely integrate the actions of multiple systemic signals to adjust the activity of stem cell lineages in response to changes in physiological status. Summary: Hormones are inextricably linked to animal physiology and can control stem cells and their local niches. Elucidating the molecular mechanisms of hormone signaling in stem cells is essential for our understanding of the fundamental underpinnings of stem cell biology and for informing new therapeutic interventions against cancers or for regenerative medicine.

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Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary

Abstract

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