TY - JOUR
T1 - Sterilizing activity of thioridazine in combination with the first-line regimen against acute murine tuberculosis
AU - Dutta, Noton K.
AU - Pinn, Michael L.
AU - Karakousis, Petros C.
PY - 2014/9
Y1 - 2014/9
N2 - We recently reported that in lung tissue, thioridazine accumulates at high concentrations relative to serum levels, displaying modest synergy with isoniazid and reducing the emergence of isoniazid-resistant mutants in mouse lungs. In this study, we sought to investigate the sterilizing activity of human-equivalent doses of thioridazine when given in combination with the "Denver regimen" against acute murine tuberculosis. We found a trend toward a positive impact of thioridazine on the bacterial clearance and lowering relapse rates of the combined standard TB chemotherapy.
AB - We recently reported that in lung tissue, thioridazine accumulates at high concentrations relative to serum levels, displaying modest synergy with isoniazid and reducing the emergence of isoniazid-resistant mutants in mouse lungs. In this study, we sought to investigate the sterilizing activity of human-equivalent doses of thioridazine when given in combination with the "Denver regimen" against acute murine tuberculosis. We found a trend toward a positive impact of thioridazine on the bacterial clearance and lowering relapse rates of the combined standard TB chemotherapy.
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U2 - 10.1128/AAC.03408-14
DO - 10.1128/AAC.03408-14
M3 - Article
C2 - 24936590
AN - SCOPUS:84906076108
SN - 0066-4804
VL - 58
SP - 5567
EP - 5569
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 9
ER -