EFFICACITE STERILISANTE DE L'ISONIAZIDE ET DU PYRAZINAMIDE EN ASSOCIATION AVEC LA RIFAMPICINE DANS LA TUBERCULOSE EXPERIMENTALE DE LA SOURIS

Mice inoculated with M. tuberculosis were treated for the 3 initial months with a combination of rifampicin (RMP) and isoniazid (INH). For the 3 following months, they were treated with either RMP alone or RMP + INH or RMP + INH + pyrazinamide (PZA). After 6 months of follow-up without treatment, there were 66%, 60% and 58% of lung and/or spleen positive cultures in the mice that received, respectively, RMP alone, RMP + INH or RMP + INH + PZA for the last 3 months. There is no evidence that adding either INH or INH + PZA to RMP in the continuation phase of treatment conferred a benefit over RMP alone.