Stereospecificity of interaction of neuroleptic drugs with neurotransmitters and correlation with clinical potency

S. J. Enna; J. P. Bennett; D. R. Burt; I. Creese; Solomon H. Snyder

doi:10.1038/263338a0

Stereospecificity of interaction of neuroleptic drugs with neurotransmitters and correlation with clinical potency

S. J. Enna, J. P. Bennett, D. R. Burt, I. Creese, Solomon H. Snyder

School of Medicine

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Abstract

THE molecular mechanism responsible for the therapeutic activity of a drug is often suggested by the biochemical event which correlates best with clinical potency. Thus, if optical or geometrical isomers of a drug have markedly different clinical potencies, the most relevant biochemical effect should also exhibit isomeric specificity.

Original language	English (US)
Pages (from-to)	338-341
Number of pages	4
Journal	Nature
Volume	263
Issue number	5575
DOIs	https://doi.org/10.1038/263338a0
State	Published - Dec 1 1976

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abstract = "THE molecular mechanism responsible for the therapeutic activity of a drug is often suggested by the biochemical event which correlates best with clinical potency. Thus, if optical or geometrical isomers of a drug have markedly different clinical potencies, the most relevant biochemical effect should also exhibit isomeric specificity.",

author = "Enna, {S. J.} and Bennett, {J. P.} and Burt, {D. R.} and I. Creese and Snyder, {Solomon H.}",

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AU - Snyder, Solomon H.

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Stereospecificity of interaction of neuroleptic drugs with neurotransmitters and correlation with clinical potency

Abstract

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