Stereoselective synthesis and biological studies of the C2 and C3 epimer and the enantiomer of pachastrissamine (Jaspine B)

G. Jayachitra; N. Sudhakar; Ravi Kumar Anchoori; B. Venkateswara Rao; Sayantani Roy; Rajkumar Banerjee

doi:10.1055/s-0029-1217096

Stereoselective synthesis and biological studies of the C2 and C3 epimer and the enantiomer of pachastrissamine (Jaspine B)

G. Jayachitra, N. Sudhakar, Ravi Kumar Anchoori, B. Venkateswara Rao, Sayantani Roy, Rajkumar Banerjee

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The synthesis of the C2 and C3 epimer and also the enantiomer of jaspine B from d-glucose is reported. The cytotoxicity of these isomers along with jaspine B and its C2 epimer on MCF7 cells has been correlated with commercially available anticancer drug Epirubicin.

Original language	English (US)
Pages (from-to)	115-119
Number of pages	5
Journal	Synthesis
Issue number	1
DOIs	https://doi.org/10.1055/s-0029-1217096
State	Published - 2010
Externally published	Yes

Keywords

Cytotoxicity
D-glucose
Jaspine B
Mitsunobu inversion
Pachastrissamine
Wittig olefination

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1055/s-0029-1217096

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abstract = "The synthesis of the C2 and C3 epimer and also the enantiomer of jaspine B from d-glucose is reported. The cytotoxicity of these isomers along with jaspine B and its C2 epimer on MCF7 cells has been correlated with commercially available anticancer drug Epirubicin.",

keywords = "Cytotoxicity, D-glucose, Jaspine B, Mitsunobu inversion, Pachastrissamine, Wittig olefination",

author = "G. Jayachitra and N. Sudhakar and Anchoori, {Ravi Kumar} and Rao, {B. Venkateswara} and Sayantani Roy and Rajkumar Banerjee",

year = "2010",

doi = "10.1055/s-0029-1217096",

language = "English (US)",

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journal = "Synthesis",

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AU - Jayachitra, G.

AU - Sudhakar, N.

AU - Anchoori, Ravi Kumar

AU - Rao, B. Venkateswara

AU - Roy, Sayantani

AU - Banerjee, Rajkumar

PY - 2010

Y1 - 2010

N2 - The synthesis of the C2 and C3 epimer and also the enantiomer of jaspine B from d-glucose is reported. The cytotoxicity of these isomers along with jaspine B and its C2 epimer on MCF7 cells has been correlated with commercially available anticancer drug Epirubicin.

AB - The synthesis of the C2 and C3 epimer and also the enantiomer of jaspine B from d-glucose is reported. The cytotoxicity of these isomers along with jaspine B and its C2 epimer on MCF7 cells has been correlated with commercially available anticancer drug Epirubicin.

KW - Cytotoxicity

KW - D-glucose

KW - Jaspine B

KW - Mitsunobu inversion

KW - Pachastrissamine

KW - Wittig olefination

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IS - 1

ER -

Stereoselective synthesis and biological studies of the C2 and C3 epimer and the enantiomer of pachastrissamine (Jaspine B)

Abstract

Keywords

ASJC Scopus subject areas

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