TY - JOUR
T1 - Stem cells, their niches and the systemic environment
T2 - An aging network
AU - Drummond-Barbosa, Daniela
PY - 2008/12
Y1 - 2008/12
N2 - Stem cells have a fascinating biology and offer great prospects for therapeutic applications, stimulating intense research on what controls their properties and behavior. Although there have been significant advances in our understanding of how local microenvironments, or niches, control the maintenance and activity of stem cells, it is much less well understood how stem cells sense and respond to variable external, physiological, or tissue environments. This review focuses on the multidirectional interactions among stem cells, niches, tissues, and the systemic environment and on potential ideas for how changes in this network of communication may relate to the aging process.
AB - Stem cells have a fascinating biology and offer great prospects for therapeutic applications, stimulating intense research on what controls their properties and behavior. Although there have been significant advances in our understanding of how local microenvironments, or niches, control the maintenance and activity of stem cells, it is much less well understood how stem cells sense and respond to variable external, physiological, or tissue environments. This review focuses on the multidirectional interactions among stem cells, niches, tissues, and the systemic environment and on potential ideas for how changes in this network of communication may relate to the aging process.
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U2 - 10.1534/genetics.108.098244
DO - 10.1534/genetics.108.098244
M3 - Review article
C2 - 19087970
AN - SCOPUS:61849161599
SN - 0016-6731
VL - 180
SP - 1787
EP - 1797
JO - Genetics
JF - Genetics
IS - 4
ER -