Stem cell therapy in bone repair and regeneration

Neeha Zaidi, Alan J. Nixon

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Stem cells of various origins, particularly endothelial progenitor cells (EPCs), have potential to enhance bone repair and regeneration. EPCs are resident in the bone marrow and home to ischemic sites to initiate vasculogenesis. Although it was previously believed that only local endothelial cells arrive at ischemic sites, new evidence suggests that EPCs are recruited from the periphery. This finding has a considerable array of therapeutic implications. For example, administered EPCs can localize to sites of osteogenesis where they increase blood vessel formation; this may be useful in enhancing fracture repair.

Original languageEnglish (US)
Pages (from-to)62-72
Number of pages11
JournalAnnals of the New York Academy of Sciences
StatePublished - Nov 2007
Externally publishedYes


  • Bone
  • Endothelial progenitor cells
  • Fracture repair
  • Mesenchymal stem cells
  • Stem cells

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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