Stem cell therapy for glaucoma: Possibilities and practicalities

Thomas V. Johnson; Natalie D. Bull; Keith R. Martin

doi:10.1586/eop.11.3

Stem cell therapy for glaucoma: Possibilities and practicalities

Thomas V. Johnson, Natalie D. Bull, Keith R. Martin

School of Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Glaucoma is a progressive, neurodegenerative, optic neuropathy in which currently available therapies cannot always prevent, and do not reverse, vision loss. Stem cell transplantation may provide a promising new avenue for treating many presently incurable degenerative conditions, including glaucoma. This article will explore the various ways in which transplantation of stem or progenitor cells may be applied for the treatment of glaucoma. We will critically discuss the translational prospects of two cell transplantation-based treatment modalities: neuroprotection and retinal ganglion cell replacement. In addition, we will identify specific questions that need to be addressed and obstacles to overcome on the path to clinical translation, and offer insight into potential strategies for approaching this goal.

Original language	English (US)
Pages (from-to)	165-174
Number of pages	10
Journal	Expert Review of Ophthalmology
Volume	6
Issue number	2
DOIs	https://doi.org/10.1586/eop.11.3
State	Published - Apr 2011

Keywords

cell replacement
glaucoma
neuroprotection
optic nerve
progenitor cell
retinal ganglion cell
stem cell
transplantation

ASJC Scopus subject areas

Biomedical Engineering
Ophthalmology
Optometry

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10.1586/eop.11.3

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title = "Stem cell therapy for glaucoma: Possibilities and practicalities",

abstract = "Glaucoma is a progressive, neurodegenerative, optic neuropathy in which currently available therapies cannot always prevent, and do not reverse, vision loss. Stem cell transplantation may provide a promising new avenue for treating many presently incurable degenerative conditions, including glaucoma. This article will explore the various ways in which transplantation of stem or progenitor cells may be applied for the treatment of glaucoma. We will critically discuss the translational prospects of two cell transplantation-based treatment modalities: neuroprotection and retinal ganglion cell replacement. In addition, we will identify specific questions that need to be addressed and obstacles to overcome on the path to clinical translation, and offer insight into potential strategies for approaching this goal.",

keywords = "cell replacement, glaucoma, neuroprotection, optic nerve, progenitor cell, retinal ganglion cell, stem cell, transplantation",

author = "Johnson, {Thomas V.} and Bull, {Natalie D.} and Martin, {Keith R.}",

note = "Funding Information: Thomas V Johnson is supported by a NIH OxCam Scholarship and the Johns Hopkins Medical Scientist Training Program (NIH Grant T32-GM007309). Natalie D Bull and Keith R Martin are supported by Fight for Sight (UK). Keith R Martin is also supported by the Cambridge NIHR Biomedical Research Centre and the Jukes Glaucoma Research Fund. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",

year = "2011",

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doi = "10.1586/eop.11.3",

language = "English (US)",

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AU - Bull, Natalie D.

AU - Martin, Keith R.

N1 - Funding Information: Thomas V Johnson is supported by a NIH OxCam Scholarship and the Johns Hopkins Medical Scientist Training Program (NIH Grant T32-GM007309). Natalie D Bull and Keith R Martin are supported by Fight for Sight (UK). Keith R Martin is also supported by the Cambridge NIHR Biomedical Research Centre and the Jukes Glaucoma Research Fund. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2011/4

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N2 - Glaucoma is a progressive, neurodegenerative, optic neuropathy in which currently available therapies cannot always prevent, and do not reverse, vision loss. Stem cell transplantation may provide a promising new avenue for treating many presently incurable degenerative conditions, including glaucoma. This article will explore the various ways in which transplantation of stem or progenitor cells may be applied for the treatment of glaucoma. We will critically discuss the translational prospects of two cell transplantation-based treatment modalities: neuroprotection and retinal ganglion cell replacement. In addition, we will identify specific questions that need to be addressed and obstacles to overcome on the path to clinical translation, and offer insight into potential strategies for approaching this goal.

AB - Glaucoma is a progressive, neurodegenerative, optic neuropathy in which currently available therapies cannot always prevent, and do not reverse, vision loss. Stem cell transplantation may provide a promising new avenue for treating many presently incurable degenerative conditions, including glaucoma. This article will explore the various ways in which transplantation of stem or progenitor cells may be applied for the treatment of glaucoma. We will critically discuss the translational prospects of two cell transplantation-based treatment modalities: neuroprotection and retinal ganglion cell replacement. In addition, we will identify specific questions that need to be addressed and obstacles to overcome on the path to clinical translation, and offer insight into potential strategies for approaching this goal.

KW - cell replacement

KW - glaucoma

KW - neuroprotection

KW - optic nerve

KW - progenitor cell

KW - retinal ganglion cell

KW - stem cell

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Stem cell therapy for glaucoma: Possibilities and practicalities

Abstract

Keywords

ASJC Scopus subject areas

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