Stem cell differentiation is regulated by extracellular matrix mechanics

Lucas R. Smith; Sangkyun Cho; Dennis E. Discher

doi:10.1152/physiol.00026.2017

Stem cell differentiation is regulated by extracellular matrix mechanics

Lucas R. Smith
, Sangkyun Cho
, Dennis E. Discher

Research output: Contribution to journal › Review article › peer-review

Abstract

Stem cells mechanosense the stiffness of their microenvironment, which impacts differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix (ECM) stiffness is clearly transduced into gene expression via adhesion and cytoskeleton proteins that tune fates. Cytoskeletal reorganization of ECM can create heterogeneity and influence fates, with fibrosis being one extreme.

Original language	English (US)
Pages (from-to)	16-25
Number of pages	10
Journal	Physiology
Volume	33
Issue number	1
DOIs	https://doi.org/10.1152/physiol.00026.2017
State	Published - Jan 2018
Externally published	Yes

ASJC Scopus subject areas

Physiology

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10.1152/physiol.00026.2017

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title = "Stem cell differentiation is regulated by extracellular matrix mechanics",

abstract = "Stem cells mechanosense the stiffness of their microenvironment, which impacts differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix (ECM) stiffness is clearly transduced into gene expression via adhesion and cytoskeleton proteins that tune fates. Cytoskeletal reorganization of ECM can create heterogeneity and influence fates, with fibrosis being one extreme.",

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note = "Publisher Copyright: {\textcopyright} 2018 Int. Union Physiol. Sci./Am. Physiol. Soc.",

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doi = "10.1152/physiol.00026.2017",

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AU - Discher, Dennis E.

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AB - Stem cells mechanosense the stiffness of their microenvironment, which impacts differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix (ECM) stiffness is clearly transduced into gene expression via adhesion and cytoskeleton proteins that tune fates. Cytoskeletal reorganization of ECM can create heterogeneity and influence fates, with fibrosis being one extreme.

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DO - 10.1152/physiol.00026.2017

M3 - Review article

C2 - 29212889

AN - SCOPUS:85037654596

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VL - 33

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JO - Physiology

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Stem cell differentiation is regulated by extracellular matrix mechanics

Abstract

ASJC Scopus subject areas

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