Steep Rebound of Chloroquine-Sensitive Plasmodium falciparum in Zimbabwe

Sungano Mharakurwa; Zvifadzo Matsena-Zingoni; Nobert Mudare; Charmaine Matimba; Tanatswa Xuxa Gara; Aramu Makuwaza; Gladys Maponga; Shungu Munyati; Lovemore Gwanzura; Susan L. Mutambu; Peter Mason; Tamaki Kobayashi; Nicholas Midzi; William J. Moss; Matthew M. Ippolito

doi:10.1093/infdis/jiaa368

Steep Rebound of Chloroquine-Sensitive Plasmodium falciparum in Zimbabwe

Sungano Mharakurwa, Zvifadzo Matsena-Zingoni, Nobert Mudare, Charmaine Matimba, Tanatswa Xuxa Gara, Aramu Makuwaza, Gladys Maponga, Shungu Munyati, Lovemore Gwanzura, Susan L. Mutambu, Peter Mason, Tamaki Kobayashi, Nicholas Midzi, William J. Moss, Matthew M. Ippolito

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Removal of chloroquine from national malaria formularies can lead to the reversion of resistant Plasmodium falciparum to wild-type. We report a steep decline in chloroquine-resistant P falciparum within 10 years of national discontinuation of chloroquine monotherapy in Zimbabwe. Drug resistance surveillance is a vital component of malaria control programs, and the experience with chloroquine in Zimbabwe and elsewhere in sub-Saharan Africa is illustrative of the potentially rapid and dramatic impact of drug policy on antimalarial resistance.

Original language	English (US)
Pages (from-to)	306-309
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	223
Issue number	2
DOIs	https://doi.org/10.1093/infdis/jiaa368
State	Published - Jan 15 2021

Keywords

Plasmodium falciparum
Zimbabwe
chloroquine
drug resistance
malaria

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/jiaa368

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Mharakurwa, S., Matsena-Zingoni, Z., Mudare, N., Matimba, C., Gara, T. X., Makuwaza, A., Maponga, G., Munyati, S., Gwanzura, L., Mutambu, S. L., Mason, P., Kobayashi, T., Midzi, N., Moss, W. J., & Ippolito, M. M. (2021). Steep Rebound of Chloroquine-Sensitive Plasmodium falciparum in Zimbabwe. Journal of Infectious Diseases, 223(2), 306-309. https://doi.org/10.1093/infdis/jiaa368

Mharakurwa, S, Matsena-Zingoni, Z, Mudare, N, Matimba, C, Gara, TX, Makuwaza, A, Maponga, G, Munyati, S, Gwanzura, L, Mutambu, SL, Mason, P, Kobayashi, T, Midzi, N, Moss, WJ & Ippolito, MM 2021, 'Steep Rebound of Chloroquine-Sensitive Plasmodium falciparum in Zimbabwe', Journal of Infectious Diseases, vol. 223, no. 2, pp. 306-309. https://doi.org/10.1093/infdis/jiaa368

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AU - Gara, Tanatswa Xuxa

AU - Makuwaza, Aramu

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Steep Rebound of Chloroquine-Sensitive Plasmodium falciparum in Zimbabwe

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Keywords

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