Abstract
Removal of chloroquine from national malaria formularies can lead to the reversion of resistant Plasmodium falciparum to wild-type. We report a steep decline in chloroquine-resistant P falciparum within 10 years of national discontinuation of chloroquine monotherapy in Zimbabwe. Drug resistance surveillance is a vital component of malaria control programs, and the experience with chloroquine in Zimbabwe and elsewhere in sub-Saharan Africa is illustrative of the potentially rapid and dramatic impact of drug policy on antimalarial resistance.
Original language | English (US) |
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Pages (from-to) | 306-309 |
Number of pages | 4 |
Journal | Journal of Infectious Diseases |
Volume | 223 |
Issue number | 2 |
DOIs | |
State | Published - Jan 15 2021 |
Keywords
- Plasmodium falciparum
- Zimbabwe
- chloroquine
- drug resistance
- malaria
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases