@article{209a7f871cdb44e8993a124b211ebb69,
title = "Stearidonic-Enriched Soybean Oil Modulates Obesity, Glucose Metabolism, and Fatty Acid Profiles Independently of Akkermansia muciniphila",
abstract = "Scope: Previous studies have suggested that diets rich in omega-3 and low in omega-6 long-chain polyunsaturated fatty acids (PUFAs) can limit the development of metabolic syndrome (MetS). Transgenic soybeans yielding oils enriched for omega-3 PUFAs represent a new and readily-available option for incorporating omega-3 PUFAs into diets to provide health benefits. Methods and Results: Transgenic soybean oils, enriched for either stearidonic acid (SDA) or eicosapentaenoic acid (EPA), are incorporated into diets to test their effects on limiting the development of MetS in a mouse model of diet-induced obesity. Supplementation with SDA- but not EPA-enriched oils improved features of MetS compared to feeding a control wild-type oil. Because previous studies have linked the gut microorganism Akkermansia muciniphila to the metabolic effects of feeding omega-3 PUFAs, the causal contribution of A. muciniphila to mediating the metabolic benefits provided by SDA-enriched diets is investigated. Although A. muciniphila is not required for SDA-induced metabolic improvements, this microorganism does modulate levels of saturated and mono-unsaturated fatty acids in host adipose tissues. Conclusion: Together, these findings support the utilization of SDA-enriched diets to modulate weight gain, glucose metabolism, and fatty acid profiles of liver and adipose tissue.",
keywords = "Akkermansia muciniphila, metabolic syndrome, polyunsaturated fatty acids, soybean oil",
author = "{Segura Munoz}, {Rafael R.} and Truyen Quach and Gomes-Neto, {Jo{\~a}o C.} and Yibo Xian and Pena, {Pamela A.} and Steven Weier and Pellizzon, {Michael A.} and Hatem Kittana and Cody, {Liz A.} and Geis, {Abby L.} and Kari Heck and Schmaltz, {Robert J.} and Bindels, {Laure B.} and Cahoon, {Edgar B.} and Benson, {Andrew K.} and Clemente, {Tom Elmo} and Ramer-Tait, {Amanda E.}",
note = "Funding Information: The authors wish to thank the staff at the UNL Gnotobiotic Mouse Facility for their technical expertise and skillful animal husbandry. This work was supported by the National Institute of General Medical Sciences of the National Institutes of Health (1P20GM104320), a Nebraska Research Initiative Grant, and start‐up funding from the University of Nebraska‐Lincoln to ART. The funders had no role in the study design, data collection, and analysis, decision to publish, or preparation of the manuscript. Funding Information: The authors wish to thank the staff at the UNL Gnotobiotic Mouse Facility for their technical expertise and skillful animal husbandry. This work was supported by the National Institute of General Medical Sciences of the National Institutes of Health (1P20GM104320), a Nebraska Research Initiative Grant, and start-up funding from the University of Nebraska-Lincoln to ART. The funders had no role in the study design, data collection, and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2020",
month = sep,
day = "1",
doi = "10.1002/mnfr.202000162",
language = "English (US)",
volume = "64",
journal = "Molecular Nutrition and Food Research",
issn = "1613-4125",
publisher = "Wiley-VCH Verlag",
number = "17",
}