TY - JOUR
T1 - STATs in cancer inflammation and immunity
T2 - A leading role for STAT3
AU - Yu, Hua
AU - Pardoll, Drew
AU - Jove, Richard
PY - 2009/11
Y1 - 2009/11
N2 - Commensurate with their roles in regulating cytokine-dependent inflammation and immunity, signal transducer and activator of transcription (STAT) proteins are central in determining whether immune responses in the tumour microenvironment promote or inhibit cancer. Persistently activated STAT3 and, to some extent, STAT5 increase tumour cell proliferation, survival and invasion while suppressing anti-tumour immunity. The persistent activation of STAT3 also mediates tumour-promoting inflammation. STAT3 has this dual role in tumour inflammation and immunity by promoting pro-oncogenic inflammatory pathways, including nuclear factor-B (NF-B) and interleukin-6 (IL-6)-GP130-Janus kinase (JAK) pathways, and by opposing STAT1-and NF-B-mediated T helper 1 anti-tumour immune responses. Consequently, STAT3 is a promising target to redirect inflammation for cancer therapy.
AB - Commensurate with their roles in regulating cytokine-dependent inflammation and immunity, signal transducer and activator of transcription (STAT) proteins are central in determining whether immune responses in the tumour microenvironment promote or inhibit cancer. Persistently activated STAT3 and, to some extent, STAT5 increase tumour cell proliferation, survival and invasion while suppressing anti-tumour immunity. The persistent activation of STAT3 also mediates tumour-promoting inflammation. STAT3 has this dual role in tumour inflammation and immunity by promoting pro-oncogenic inflammatory pathways, including nuclear factor-B (NF-B) and interleukin-6 (IL-6)-GP130-Janus kinase (JAK) pathways, and by opposing STAT1-and NF-B-mediated T helper 1 anti-tumour immune responses. Consequently, STAT3 is a promising target to redirect inflammation for cancer therapy.
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U2 - 10.1038/nrc2734
DO - 10.1038/nrc2734
M3 - Review article
C2 - 19851315
AN - SCOPUS:70350500225
SN - 1474-175X
VL - 9
SP - 798
EP - 809
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 11
ER -