TY - JOUR
T1 - Statins impair glucose uptake in tumor cells
AU - Ganapathy-Kanniappan, Shanmugasundaram
AU - Kunjithapatham, Rani
AU - Geschwind, Jean Francois H.
N1 - Funding Information:
Abbreviations: 2-DOG, 2-deoxyglucose; 6-NBDG, 6-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-6-deoxyglucose; CD, cluster of differentiation; CRAC, cholesterol recognition/ interaction amino acid consensus; 18F-FDG, [18F]fluoro-2-deoxyglucose; FPP, farnesyl pyrophosphate; GLUT, glucose transporter; HA, hemagglutinin; MA, mevalonic acid; MβCD, methyl-β-cyclodextrin; PBMC, peripheral blood mononuclear cell; PET/CT, positron emission tomography/computed tomography; SUV, standardized uptake value Address all correspondence to: Dominika A. Nowis, MD, PhD, Department of Immunology, Center of Biostructure Research, The Medical University of Warsaw, 1a Banacha Str., F Bldg, 02-097 Warsaw, Poland. E-mail: [email protected] 1J.G., A.M., and D.N. are recipients of the Mistrz Award from the Foundation for Polish Science. J.G., M.W., and M.F. are members of TEAM Programme co-financed by the Foundation for Polish Science and the EU European Regional Development Fund. The research was supported by grants 1M19/NM1 (to A.M.), 1M19/NM6 (to A.M.), and 1W13/ W1/10 (to L.K.) from the Medical University of Warsaw, N N402 365438 (to J.G.), N N405 302836 (to M.J.) from Polish Ministry of Science, the European Union within European Regional Development Fund through Innovative Economy grant POIG.01.01.02-00-008/08 (to J.G.) as well as by grant N R13 0094 06 (to K.K.) from The National Centre for Research and Development. The work carried out by J.M.B. (modeling of GLUT1) was supported by the 7th Framework Programme of the European Commission (EC FP7, grant HEALTHPROT, contract number 229676). None of these organizations had any influence neither on the course of the studies nor on the preparation of the article. Received 26 February 2012; Revised 22 March 2012; Accepted 22 March 2012 Copyright © 2012 Neoplasia Press, Inc. All rights reserved 1522-8002/12/$25.00 DOI 10.1593/neo.12444
PY - 2013/2
Y1 - 2013/2
N2 - Statins play a pivotal role in lowering the blood cholesterol level, which is critical for patients with hypercholesterolemia. In addition to its benefits in cardiovascular protection, statins have been found to be useful in several other clinical conditions, including cancer. In a recent report that appeared in Neoplasia, Malenda et al., have demonstrated that statins inhibit glucose uptake in cancer cells. Using multiple statins and glucose analogs (18FDG and 6-NBDG) they showed that inhibition of cholesterol synthesis underlies the blockade of glucose uptake in several cancer cell lines. Further, based on an exploratory clinical study, they also showed that diagnostic PET-CT imaging in patients treated for hypercholesterolemia was affected due to statin-mediated inhibition of glucose uptake. As the finding is based on the data from a single patient (out of four), it seems that (1) the need for a large cohort study and (2) the detailed characterization of the molecular mechanisms underlying such biological effects would be justified.
AB - Statins play a pivotal role in lowering the blood cholesterol level, which is critical for patients with hypercholesterolemia. In addition to its benefits in cardiovascular protection, statins have been found to be useful in several other clinical conditions, including cancer. In a recent report that appeared in Neoplasia, Malenda et al., have demonstrated that statins inhibit glucose uptake in cancer cells. Using multiple statins and glucose analogs (18FDG and 6-NBDG) they showed that inhibition of cholesterol synthesis underlies the blockade of glucose uptake in several cancer cell lines. Further, based on an exploratory clinical study, they also showed that diagnostic PET-CT imaging in patients treated for hypercholesterolemia was affected due to statin-mediated inhibition of glucose uptake. As the finding is based on the data from a single patient (out of four), it seems that (1) the need for a large cohort study and (2) the detailed characterization of the molecular mechanisms underlying such biological effects would be justified.
KW - Cancer
KW - Cholesterol
KW - FDG
KW - GLUT1
KW - Glucose uptake
KW - PET imaging
KW - Statins
UR - http://www.scopus.com/inward/record.url?scp=84873466696&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873466696&partnerID=8YFLogxK
U2 - 10.4161/cbt.23290
DO - 10.4161/cbt.23290
M3 - Article
C2 - 23254955
AN - SCOPUS:84873466696
SN - 1538-4047
VL - 14
SP - 92
EP - 94
JO - Cancer Biology and Therapy
JF - Cancer Biology and Therapy
IS - 2
ER -