Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis

Stephen J. Nicholls, E. Murat Tuzcu, Ilke Sipahi, Adam W. Grasso, Paul Schoenhagen, Tingfei Hu, Kathy Wolski, Tim Crowe, Milind Y. Desai, Stanley L. Hazen, Samir R. Kapadia, Steven E. Nissen

Research output: Contribution to journalArticlepeer-review

592 Scopus citations


Context: Statins reduce low-density lipoprotein cholesterol (LDL-C) levels and slow progression of coronary atherosclerosis. However, no data exist describing the relationship between statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and disease progression. Objective: To investigate the relationship between changes in LDL-C and HDL-C levels and atheroma burden. Design, Setting, and Patients: Post-hoc analysis combining raw data from 4 prospective randomized trials (performed in the United States, North America, Europe, and Australia between 1999 and 2005), in which 1455 patients with angiographic coronary disease underwent serial intravascular ultrasonography while receiving statin treatment for 18 months or for 24 months. Ultrasound analysis was performed in the same core laboratory for all of the studies. Main Outcome Measure: Relationship between changes in lipoprotein levels and coronary artery atheroma volume. Results: During statin therapy, mean (SD) LDL-C levels were reduced from 124.0 (38.3) mg/dL (3.2 [0.99] mmol/L) to 87.5 (28.8) mg/dL (2.3 [0.75] mmol/L) (a 23.5% decrease; P3 (P

Original languageEnglish (US)
Pages (from-to)499-508
Number of pages10
JournalJournal of the American Medical Association
Issue number5
StatePublished - Feb 7 2007
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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