TY - JOUR
T1 - State- and trait-dependent associations of vitamin-D with brain function during aging
AU - Kueider, Alexandra M.
AU - Tanaka, Toshiko
AU - An, Yang
AU - Kitner-Triolo, Melissa H.
AU - Palchamy, Elango
AU - Ferrucci, Luigi
AU - Thambisetty, Madhav
PY - 2016/3/1
Y1 - 2016/3/1
N2 - We investigated whether (1) serum levels of 25-hydroxyvitamin D [25(OH)D] and single nucleotide polymorphisms (SNPs) in the group-specific component (GC) gene-regulating serum 25(OH)D levels are associated with cognition in older individuals; and (2) whether causal relationships exist between 25(OH)D and cognition during aging. Data from 1207 participants in the Baltimore Longitudinal Study of Aging were analyzed (mean follow-up, 10.4 years) to test associations between serum 25(OH)D and cognition. Two GC SNPs were used to derive a composite genetic risk score associated with lower 25(OH)D concentrations. Lower serum 25(OH)D and higher GC composite scores were associated with lower executive function at baseline. Mendelian randomization analyses suggested a causal relationship between lower serum 25(OH)D and poorer executive function and psychomotor speed. The SNP score was also associated with lower performance on measures of visuospatial abilities at baseline but with attenuated declines over time in visuospatial abilities and executive function. Widespread associations between vitamin-D regulatory SNPs and cognition suggest a mechanistic basis for the relationship between serum 25(OH)D levels and cognition during aging.
AB - We investigated whether (1) serum levels of 25-hydroxyvitamin D [25(OH)D] and single nucleotide polymorphisms (SNPs) in the group-specific component (GC) gene-regulating serum 25(OH)D levels are associated with cognition in older individuals; and (2) whether causal relationships exist between 25(OH)D and cognition during aging. Data from 1207 participants in the Baltimore Longitudinal Study of Aging were analyzed (mean follow-up, 10.4 years) to test associations between serum 25(OH)D and cognition. Two GC SNPs were used to derive a composite genetic risk score associated with lower 25(OH)D concentrations. Lower serum 25(OH)D and higher GC composite scores were associated with lower executive function at baseline. Mendelian randomization analyses suggested a causal relationship between lower serum 25(OH)D and poorer executive function and psychomotor speed. The SNP score was also associated with lower performance on measures of visuospatial abilities at baseline but with attenuated declines over time in visuospatial abilities and executive function. Widespread associations between vitamin-D regulatory SNPs and cognition suggest a mechanistic basis for the relationship between serum 25(OH)D levels and cognition during aging.
KW - Cognitive performance
KW - Mendelian randomization
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84959550561&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959550561&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2015.11.002
DO - 10.1016/j.neurobiolaging.2015.11.002
M3 - Article
C2 - 26923400
AN - SCOPUS:84959550561
SN - 0197-4580
VL - 39
SP - 38
EP - 45
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -