STAR*D: Helping to close the gap between science and practice

David L. Shern, Hazel Moran

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Practical clinical trials, such as STAR*D (Sequenced Treatment Alternatives to Relieve Depression), extend the traditional randomized controlled trial to real-world settings. Consumers and clinicians should be encouraged by STAR*D's 70% remission rate and should realize that for many participants remission required medication switching and augmentation. Policy makers should recognize the importance of easy access to a full range of treatments. Researchers should be sobered by the high attrition rate and the 30% of participants who did not achieve remission. Although more such practical trials are needed, future work must more meaningfully involve consumers in design, analysis, and interpretation.

Original languageEnglish (US)
Pages (from-to)1458-1459
Number of pages2
JournalPsychiatric Services
Issue number11
StatePublished - Nov 2009
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Medicine(all)


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