@article{2a94c89639a64e68a3b015fce1d3029e,
title = "Standardized Measurement of Sensorimotor Recovery in Stroke Trials: Consensus-Based Core Recommendations from the Stroke Recovery and Rehabilitation Roundtable",
abstract = "Finding, testing and demonstrating efficacy of new treatments for stroke recovery is a multifaceted challenge. We believe that to advance the field, neurorehabilitation trials need a conceptually rigorous starting framework. An essential first step is to agree on definitions of sensorimotor recovery and on measures consistent with these definitions. Such standardization would allow pooling of participant data across studies and institutions aiding meta-analyses of completed trials, more detailed exploration of recovery profiles of our patients and the generation of new hypotheses. Here, we present the results of a consensus meeting about measurement standards and patient characteristics that we suggest should be collected in all future stroke recovery trials. Recommendations are made considering time post stroke and are aligned with the international classification of functioning and disability. A strong case is made for addition of kinematic and kinetic movement quantification. Further work is being undertaken by our group to form consensus on clinical predictors and pre-stroke clinical data that should be collected, as well as recommendations for additional outcome measurement tools. To improve stroke recovery trials, we urge the research community to consider adopting our recommendations in their trial design.",
keywords = "Clinical research, international, outcomes, recommendations, recovery, stroke",
author = "Gert Kwakkel and Lannin, {Natasha A.} and Karen Borschmann and Coralie English and Myzoon Ali and Leonid Churilov and Gustavo Saposnik and Carolee Winstein and {Van Wegen}, {Erwin E.H.} and Wolf, {Steven L.} and Krakauer, {John W.} and Julie Bernhardt",
note = "Funding Information: We acknowledge the following organizations for their financial support of the meeting: NHMRC CRE Stroke Rehabilitation & Brain Recovery (Australia), Heart and Stroke Foundation of Canada, Heart and Stroke Foundation Canadian Partnership for Stroke Recovery. An unrestricted educational grant was provided by Ipsen Pharma.The Florey Institute of Neuroscience and Mental Health acknowledges support from the Victorian Government, in particular funding from the Operational Infrastructure Support Grant. Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: JB was supported by NHMRC (1058635) and NL holds a NHMRC TRIP fellowship (GNT1112158). Funding Information: 1Department of Rehabilitation Medicine, Amsterdam Movement Sciences, Amsterdam Neuroscience, VU University Medical Center Amsterdam, The Netherlands; and Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, USA 2School of Allied Health, La Trobe University, Melbourne, Australia; and Department of Occupational Therapy, Alfred Health, Melbourne, Australia 3Stroke Division, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Australia 4NHMRC Centre of Research Excellence Stroke Rehabilitation and Brain Recovery, Melbourne, Australia 5University of Newcastle School of Health Sciences and Priority Research Centre for Stroke and Brain Injury, Hunter Medical Research Institute, Australia; NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery, Australia 6Nursing, Midwifery and Allied Health Professions (NMAHP) Research Unit, Glasgow Caledonian University, UK, and Institutes of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK 7Stroke Outcomes Research & Center for Virtual Reality Studies (www.sorcan.ca); Department of Medicine (Neurology), Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Canada 8Division Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry and Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA 9Department of Rehabilitation Medicine, Amsterdam Movement Sciences, Amsterdam Neuroscience, VU University Medical Center Amsterdam, The Netherlands 10Department of Rehabilitation Medicine, Division of Physical Therapy, Emory University School of Medicine, Atlanta; VA Center for Visual and Neurocognitive Rehabilitation, Atlanta, GA, USA 11Departments of Neurology, Neuroscience, and Physical Medicine & Rehabilitation, The Johns Hopkins University School of Medicine, Baltimore, MD, USA *This article was first published in International Journal of Stroke 2017, Volume 12, Issue 5, pages 451–461. To request permission to re-use any part of this article, please contact SAGE Publishing: https://uk.sagepub.com/en-gb/eur/journals-permissions. Publisher Copyright: {\textcopyright} American Society of Neurorehabilitation.",
year = "2017",
month = sep,
day = "1",
doi = "10.1177/1545968317732662",
language = "English (US)",
volume = "31",
pages = "784--792",
journal = "Neurorehabilitation and neural repair",
issn = "1545-9683",
publisher = "SAGE Publications Inc.",
number = "9",
}