Standardized drug and pharmacological class network construction

Qian Zhu, Guoqian Jiang, Liwei Wang, Christopher G. Chute

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


Dozens of drug terminologies and resources capture the drug and/or drug class information, ranging from their coverage and adequacy of representation. No transformative ways are available to link them together in a standard way, which hinders data integration and data representation for drug-related clinical and translational studies. In this paper, we introduce our preliminary work for building a standardized drug and drug class network that integrates multiple drug terminological resources, using Anatomical Therapeutic Chemical (ATC) and National Drug File Reference Terminology (NDF-RT) as network backbone, and expanding with RxNorm and Structured Product Label (SPL). The network consists of 39,728 drugs and drug classes. We calculated and compared structure similarity for each drug/drug class pair from ATC and NDF-RT, and analyzed constructed drug class network from chemical structure perspective.

Original languageEnglish (US)
Title of host publicationMEDINFO 2013 - Proceedings of the 14th World Congress on Medical and Health Informatics
PublisherIOS Press
Number of pages1
ISBN (Print)9781614992882
StatePublished - 2013
Externally publishedYes
Event14th World Congress on Medical and Health Informatics, MEDINFO 2013 - Copenhagen, Denmark
Duration: Aug 20 2013Aug 23 2013

Publication series

NameStudies in Health Technology and Informatics
ISSN (Print)0926-9630
ISSN (Electronic)1879-8365


Other14th World Congress on Medical and Health Informatics, MEDINFO 2013

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management


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