Staging of head and neck cancer

Ronald D. Ennis; Jonathan P.s. Knisely; Lynn D. Wilson; Klaus Pantel; Hans Gath; Ernst Heissler; Gary D. Kao; Marc Rudoltz; Srdjan Denic; Joseph A. Brennan; li Mao; David Sidransky

doi:10.1056/NEJM199506293322613

Staging of head and neck cancer

Ronald D. Ennis, Jonathan P.s. Knisely, Lynn D. Wilson, Klaus Pantel, Hans Gath, Ernst Heissler, Gary D. Kao, Marc Rudoltz, Srdjan Denic, Joseph A. Brennan, li Mao, David Sidransky

School of Medicine

Research output: Contribution to journal › Letter › peer-review

Abstract

To the Editor: Brennan et al. (Feb. 16 issue)¹ are to be commended for their important and well-executed study. This is an excellent example of the use of emerging molecular-biology techniques to address important clinical questions. The clinical usefulness of the study would have been augmented, however, if the authors had provided details of the radiotherapy administered. Because radiation kills cells exponentially, its success is inversely related to the log of the clonogenic cells within the treated volume.² The tumor-cell burden is higher in patients with positive margins, and it is for this reason that radiation decreases the rate of.

Original language	English (US)
Pages (from-to)	1787-1790
Number of pages	4
Journal	New England Journal of Medicine
Volume	332
Issue number	26
DOIs	https://doi.org/10.1056/NEJM199506293322613
State	Published - Jun 29 1995

ASJC Scopus subject areas

Medicine(all)

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title = "Staging of head and neck cancer",

abstract = "To the Editor: Brennan et al. (Feb. 16 issue)1 are to be commended for their important and well-executed study. This is an excellent example of the use of emerging molecular-biology techniques to address important clinical questions. The clinical usefulness of the study would have been augmented, however, if the authors had provided details of the radiotherapy administered. Because radiation kills cells exponentially, its success is inversely related to the log of the clonogenic cells within the treated volume.2 The tumor-cell burden is higher in patients with positive margins, and it is for this reason that radiation decreases the rate of.",

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T1 - Staging of head and neck cancer

AU - Ennis, Ronald D.

AU - Knisely, Jonathan P.s.

AU - Wilson, Lynn D.

AU - Pantel, Klaus

AU - Gath, Hans

AU - Heissler, Ernst

AU - Kao, Gary D.

AU - Rudoltz, Marc

AU - Denic, Srdjan

AU - Brennan, Joseph A.

AU - Mao, li

AU - Sidransky, David

PY - 1995/6/29

Y1 - 1995/6/29

N2 - To the Editor: Brennan et al. (Feb. 16 issue)1 are to be commended for their important and well-executed study. This is an excellent example of the use of emerging molecular-biology techniques to address important clinical questions. The clinical usefulness of the study would have been augmented, however, if the authors had provided details of the radiotherapy administered. Because radiation kills cells exponentially, its success is inversely related to the log of the clonogenic cells within the treated volume.2 The tumor-cell burden is higher in patients with positive margins, and it is for this reason that radiation decreases the rate of.

AB - To the Editor: Brennan et al. (Feb. 16 issue)1 are to be commended for their important and well-executed study. This is an excellent example of the use of emerging molecular-biology techniques to address important clinical questions. The clinical usefulness of the study would have been augmented, however, if the authors had provided details of the radiotherapy administered. Because radiation kills cells exponentially, its success is inversely related to the log of the clonogenic cells within the treated volume.2 The tumor-cell burden is higher in patients with positive margins, and it is for this reason that radiation decreases the rate of.

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Staging of head and neck cancer

Abstract

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