Stage IV ovarian carcinoma following ovulation induction: A report of three cases

R. E. Bristow, B. Y. Karlan

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Recent attention, in both the medical and lay communities, has been focused on a possible causal relationship between ovulation induction and ovarian carcinoma. The three cases reported here display marked heterogeneity in their risk factor profiles for ovarian cancer, illustrating several of the inconsistencies that have hampered epidemiological studies examining the proposed mutagenic effect of fertility drugs on ovarian epithelium. Three cases of stage IV invasive ovarian carcinoma, developing in infertility patients following from one to seven cycles of ovulation induction, are presented. The biological plausibility of a causal effect of fertility drugs on ovarian carcinogenesis has not been corroborated by consistent dose- dependent or lag-time effects. Fertility drug use may be an incidental finding associated with the known ovarian cancer risk factor of infertility. Nevertheless, until the precise effects of fertility drugs on ovarian epithelium are elucidated, a high index of suspicion for malignant ovarian neoplasms in women using these medications is indicated.

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalInternational Journal of Gynecological Cancer
Issue number2
StatePublished - Jan 1 1997


  • infertility
  • ovarian cancer
  • ovulation induction

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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