Abstract
Objective: Examine if the gut microbiota composition changes across repeated samples in paediatric-onset multiple sclerosis (MS) or monophasic-acquired demyelinating syndromes (monoADS). Methods: A total of 36 individuals (18 MS/18 monoADS) with ⩾2 stool samples were included. Stool sample-derived DNA was sequenced. Alpha/beta diversities and genus-level taxa were analysed. Results: Mean ages at first sample procurement (MS/monoADS) = 18.0/13.8 years. Median time (months) between first/second samples = 11.2 and second/third = 10.3. Alpha/beta diversities did not differ between stool samples (p > 0.09), while one genus – Solobacterium did (p = 0.001). Conclusions: The gut microbiota composition in paediatric-onset MS and monoADS exhibited stability, suggesting that single stool sample procurement is a reasonable first approach.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1819-1824 |
| Number of pages | 6 |
| Journal | Multiple Sclerosis Journal |
| Volume | 28 |
| Issue number | 11 |
| DOIs | |
| State | Published - Oct 2022 |
| Externally published | Yes |
Keywords
- Multiple sclerosis
- demyelinating disease
- gut microbiota
- monophasic acquired demyelinating syndrome
- paediatric
- stability
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
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