ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (ST3GAL4)

Ronald L. Schnaar

doi:10.1007/978-4-431-54240-7_75

ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (ST3GAL4)

Ronald L. Schnaar

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

ST3Gal-IV is a member of the β-galactoside α-2,3-sialyltransferase family, transferring sialic acid in α2,3 linkage from CMP-NeuAc preferentially to Galβ1-4GlcNAc termini, but also to Galβ1-3GlcNAc and Galβ1-3GalNAc termini on glycoproteins and glycolipids. Included among its acceptors is Le^x (Galβ1-4(Fucα1-3)GlcNAc) to produce sialyl Le^x, a glycan determinant important in leukocyte trafficking.

Original language	English (US)
Title of host publication	Handbook of Glycosyltransferases and Related Genes, Second Edition
Publisher	Springer Japan
Pages	667-674
Number of pages	8
Volume	2
ISBN (Electronic)	9784431542407
ISBN (Print)	9784431542391
DOIs	https://doi.org/10.1007/978-4-431-54240-7_75
State	Published - Jan 1 2014

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-4-431-54240-7_75

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abstract = "ST3Gal-IV is a member of the β-galactoside α-2,3-sialyltransferase family, transferring sialic acid in α2,3 linkage from CMP-NeuAc preferentially to Galβ1-4GlcNAc termini, but also to Galβ1-3GlcNAc and Galβ1-3GalNAc termini on glycoproteins and glycolipids. Included among its acceptors is Lex (Galβ1-4(Fucα1-3)GlcNAc) to produce sialyl Lex, a glycan determinant important in leukocyte trafficking.",

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AU - Schnaar, Ronald L.

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Y1 - 2014/1/1

N2 - ST3Gal-IV is a member of the β-galactoside α-2,3-sialyltransferase family, transferring sialic acid in α2,3 linkage from CMP-NeuAc preferentially to Galβ1-4GlcNAc termini, but also to Galβ1-3GlcNAc and Galβ1-3GalNAc termini on glycoproteins and glycolipids. Included among its acceptors is Lex (Galβ1-4(Fucα1-3)GlcNAc) to produce sialyl Lex, a glycan determinant important in leukocyte trafficking.

AB - ST3Gal-IV is a member of the β-galactoside α-2,3-sialyltransferase family, transferring sialic acid in α2,3 linkage from CMP-NeuAc preferentially to Galβ1-4GlcNAc termini, but also to Galβ1-3GlcNAc and Galβ1-3GalNAc termini on glycoproteins and glycolipids. Included among its acceptors is Lex (Galβ1-4(Fucα1-3)GlcNAc) to produce sialyl Lex, a glycan determinant important in leukocyte trafficking.

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BT - Handbook of Glycosyltransferases and Related Genes, Second Edition

PB - Springer Japan

ER -

ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (ST3GAL4)

Abstract

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