ST3Gal-III is a member of the N-acetyllactosaminide α-2,3-sialyltransferase family, transferring sialic acid from CMP-NeuAc in α-2,3 linkage preferentially to Galβ1-3GlcNAc, but also to Galβ1-4GlcNAc and Galβ1-3GalNAc termini on glycoproteins and glycolipids. It was among the first sialyltransferases purified and cloned (Wen et al. 1992), leading to the discovery of sialyltransferase sialyl motifs.
|Original language||English (US)|
|Title of host publication||Handbook of Glycosyltransferases and Related Genes, Second Edition|
|Number of pages||9|
|State||Published - Jan 1 2014|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)