Spreading Cerebral Hypoperfusion during Migraine Headache

N. Vijayan, Michael D. O’brien, J. N. Blau, Darius Rastegar, Roger P. Woods, Marco Iacoboni, John C. Mazziotta, Jes Olesen

Research output: Contribution to journalLetterpeer-review

7 Scopus citations


To the Editor: The report by Woods et al. (Dec. 22 issue)1 on spreading oligemia as demonstrated by positron-emission tomography (PET) during a spontaneous episode of migraine confirms previous observations made on the basis of conventional studies of cerebral blood flow, as discussed by Olesen in the accompanying editorial.2 It is a giant step, however, to conclude that this observation can be equated with “spreading depression,” which is primarily an observation in experiments with animals. Besides, one could ask how spreading depression leads to the clinical features of migraine — specifically, pain, the most important symptom. What is the clinical.

Original languageEnglish (US)
Pages (from-to)1516-1518
Number of pages3
JournalNew England Journal of Medicine
Issue number22
StatePublished - Jun 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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