Spotlight on Trans-Synaptic Degeneration in the Visual Pathway in Multiple Sclerosis

Angeliki G. Filippatou; Peter A. Calabresi; Shiv Saidha; Olwen C. Murphy

doi:10.2147/EB.S389632

Spotlight on Trans-Synaptic Degeneration in the Visual Pathway in Multiple Sclerosis

Angeliki G. Filippatou, Peter A. Calabresi, Shiv Saidha, Olwen C. Murphy

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

A putative mechanism of neurodegeneration in multiple sclerosis (MS) is trans-synaptic degeneration (TSD), whereby injury to a neuron leads to degeneration of synaptically connected neurons. The visual system is commonly involved in MS and provides an ideal model to study TSD given its well-defined structure. TSD may occur in an anterograde direction (optic neuropathy causing degeneration in the posterior visual pathway including the optic radiations and occipital gray matter) and/or retrograde direction (posterior visual pathway lesions causing retinal degeneration). In the current review, we discuss evidence supporting the presence of anterograde and retrograde TSD in the visual system in MS.

Original language	English (US)
Pages (from-to)	153-160
Number of pages	8
Journal	Eye and Brain
Volume	15
DOIs	https://doi.org/10.2147/EB.S389632
State	Published - 2023

Keywords

multiple sclerosis
neurodegeneration
optic neuritis
optical coherence tomography
transsynaptic degeneration

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.2147/EB.S389632

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title = "Spotlight on Trans-Synaptic Degeneration in the Visual Pathway in Multiple Sclerosis",

abstract = "A putative mechanism of neurodegeneration in multiple sclerosis (MS) is trans-synaptic degeneration (TSD), whereby injury to a neuron leads to degeneration of synaptically connected neurons. The visual system is commonly involved in MS and provides an ideal model to study TSD given its well-defined structure. TSD may occur in an anterograde direction (optic neuropathy causing degeneration in the posterior visual pathway including the optic radiations and occipital gray matter) and/or retrograde direction (posterior visual pathway lesions causing retinal degeneration). In the current review, we discuss evidence supporting the presence of anterograde and retrograde TSD in the visual system in MS.",

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AU - Filippatou, Angeliki G.

AU - Calabresi, Peter A.

AU - Saidha, Shiv

AU - Murphy, Olwen C.

PY - 2023

Y1 - 2023

N2 - A putative mechanism of neurodegeneration in multiple sclerosis (MS) is trans-synaptic degeneration (TSD), whereby injury to a neuron leads to degeneration of synaptically connected neurons. The visual system is commonly involved in MS and provides an ideal model to study TSD given its well-defined structure. TSD may occur in an anterograde direction (optic neuropathy causing degeneration in the posterior visual pathway including the optic radiations and occipital gray matter) and/or retrograde direction (posterior visual pathway lesions causing retinal degeneration). In the current review, we discuss evidence supporting the presence of anterograde and retrograde TSD in the visual system in MS.

AB - A putative mechanism of neurodegeneration in multiple sclerosis (MS) is trans-synaptic degeneration (TSD), whereby injury to a neuron leads to degeneration of synaptically connected neurons. The visual system is commonly involved in MS and provides an ideal model to study TSD given its well-defined structure. TSD may occur in an anterograde direction (optic neuropathy causing degeneration in the posterior visual pathway including the optic radiations and occipital gray matter) and/or retrograde direction (posterior visual pathway lesions causing retinal degeneration). In the current review, we discuss evidence supporting the presence of anterograde and retrograde TSD in the visual system in MS.

KW - multiple sclerosis

KW - neurodegeneration

KW - optic neuritis

KW - optical coherence tomography

KW - transsynaptic degeneration

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JO - Eye and Brain

JF - Eye and Brain

ER -

Spotlight on Trans-Synaptic Degeneration in the Visual Pathway in Multiple Sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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