Spontaneous involution of subfoveal neovascularization

P. A. Campochiaro, K. M. Morgan, B. P. Conway, J. Stathos

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


We studied five patients who maintained or spontaneously regained significant central vision despite the presence of a subfoveal neovascular membrane. Sequential photographs and fluorescein angiograms showed a pattern of development common to these patients and not observed in patients who lose all central vision. The pattern involves formation of a pigmented ring around the subfoveal neovascular membrane followed by alteration of the membrane from one that leaks fluorescein to one that stains but does not leak. This pattern is associated with gradual resorption of subretinal fluid and apparent limitation of subretinal hemorrhage and fibrosis. This course suggests the occurrence of spontaneous involution of some subfoveal neovascular membranes and implicates the retinal pigment epithelium in this process.

Original languageEnglish (US)
Pages (from-to)668-675
Number of pages8
JournalAmerican journal of ophthalmology
Issue number6
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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