Spontaneous autoimmune thyroiditis in the BUF rat.

N. R. Rose; P. E. Bigazzi; B. Noble

doi:10.1007/978-1-4684-3300-5_18

Spontaneous autoimmune thyroiditis in the BUF rat.

N. R. Rose
, P. E. Bigazzi
, B. Noble

School of Medicine

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

The inbred BUF rat develops autoimmune thyroiditis spontaneously. The incidence is related to the age of the animal and is increased by neonatal thymectomy and by treatment with methylcholanthrene. Autoantibodies to thyroglobulin can be demonstrated by indirect immunofluorescence and hemagglutination, but skin tests are negative. The "spontaneous" autoimmune disease may be due to the conjunction of an unusually vigorous immunological response to thyroglobulin and the loss of thymic suppressor function.

Original language	English (US)
Pages (from-to)	209-216
Number of pages	8
Journal	Advances in experimental medicine and biology
Volume	73 Pt B
DOIs	https://doi.org/10.1007/978-1-4684-3300-5_18
State	Published - 1976

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4684-3300-5_18

Cite this

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title = "Spontaneous autoimmune thyroiditis in the BUF rat.",

abstract = "The inbred BUF rat develops autoimmune thyroiditis spontaneously. The incidence is related to the age of the animal and is increased by neonatal thymectomy and by treatment with methylcholanthrene. Autoantibodies to thyroglobulin can be demonstrated by indirect immunofluorescence and hemagglutination, but skin tests are negative. The {"}spontaneous{"} autoimmune disease may be due to the conjunction of an unusually vigorous immunological response to thyroglobulin and the loss of thymic suppressor function.",

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T1 - Spontaneous autoimmune thyroiditis in the BUF rat.

AU - Rose, N. R.

AU - Bigazzi, P. E.

AU - Noble, B.

PY - 1976

Y1 - 1976

N2 - The inbred BUF rat develops autoimmune thyroiditis spontaneously. The incidence is related to the age of the animal and is increased by neonatal thymectomy and by treatment with methylcholanthrene. Autoantibodies to thyroglobulin can be demonstrated by indirect immunofluorescence and hemagglutination, but skin tests are negative. The "spontaneous" autoimmune disease may be due to the conjunction of an unusually vigorous immunological response to thyroglobulin and the loss of thymic suppressor function.

AB - The inbred BUF rat develops autoimmune thyroiditis spontaneously. The incidence is related to the age of the animal and is increased by neonatal thymectomy and by treatment with methylcholanthrene. Autoantibodies to thyroglobulin can be demonstrated by indirect immunofluorescence and hemagglutination, but skin tests are negative. The "spontaneous" autoimmune disease may be due to the conjunction of an unusually vigorous immunological response to thyroglobulin and the loss of thymic suppressor function.

UR - https://www.scopus.com/pages/publications/0017271126

UR - https://www.scopus.com/pages/publications/0017271126#tab=citedBy

U2 - 10.1007/978-1-4684-3300-5_18

DO - 10.1007/978-1-4684-3300-5_18

M3 - Review article

C2 - 793334

AN - SCOPUS:0017271126

SN - 0065-2598

VL - 73 Pt B

SP - 209

EP - 216

JO - Advances in experimental medicine and biology

JF - Advances in experimental medicine and biology

ER -

Spontaneous autoimmune thyroiditis in the BUF rat.

Abstract

ASJC Scopus subject areas

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