Splicing and Dicing MYC-Mediated Synthetic Lethality

Zachary E. Stine, Chi V. Dang

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations


In a recent issue of Nature, Hsu and colleagues report that oncogenic MYC activation is synthetic lethal with inhibition of the core spliceosome, because MYC-driven growth and increased transcription leave tumors dependent on pre-mRNA processing for survival. As direct targeting of MYC has remained elusive, synthetic lethal strategies are attractive.

Original languageEnglish (US)
Article number2152
Pages (from-to)405-406
Number of pages2
JournalCancer cell
Issue number4
StatePublished - Oct 12 2015
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Cell Biology


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