Splicing and Dicing MYC-Mediated Synthetic Lethality

Zachary E. Stine; Chi V. Dang

doi:10.1016/j.ccell.2015.09.016

Splicing and Dicing MYC-Mediated Synthetic Lethality

Zachary E. Stine, Chi V. Dang

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

In a recent issue of Nature, Hsu and colleagues report that oncogenic MYC activation is synthetic lethal with inhibition of the core spliceosome, because MYC-driven growth and increased transcription leave tumors dependent on pre-mRNA processing for survival. As direct targeting of MYC has remained elusive, synthetic lethal strategies are attractive.

Original language	English (US)
Article number	2152
Pages (from-to)	405-406
Number of pages	2
Journal	Cancer cell
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.ccell.2015.09.016
State	Published - Oct 12 2015
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research
Cell Biology

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10.1016/j.ccell.2015.09.016

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title = "Splicing and Dicing MYC-Mediated Synthetic Lethality",

abstract = "In a recent issue of Nature, Hsu and colleagues report that oncogenic MYC activation is synthetic lethal with inhibition of the core spliceosome, because MYC-driven growth and increased transcription leave tumors dependent on pre-mRNA processing for survival. As direct targeting of MYC has remained elusive, synthetic lethal strategies are attractive.",

author = "Stine, {Zachary E.} and Dang, {Chi V.}",

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AU - Dang, Chi V.

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N2 - In a recent issue of Nature, Hsu and colleagues report that oncogenic MYC activation is synthetic lethal with inhibition of the core spliceosome, because MYC-driven growth and increased transcription leave tumors dependent on pre-mRNA processing for survival. As direct targeting of MYC has remained elusive, synthetic lethal strategies are attractive.

AB - In a recent issue of Nature, Hsu and colleagues report that oncogenic MYC activation is synthetic lethal with inhibition of the core spliceosome, because MYC-driven growth and increased transcription leave tumors dependent on pre-mRNA processing for survival. As direct targeting of MYC has remained elusive, synthetic lethal strategies are attractive.

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ER -

Splicing and Dicing MYC-Mediated Synthetic Lethality

Abstract

ASJC Scopus subject areas

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