Spinal muscular atrophy, John Griffin, and mentorship.

Research output: Contribution to journalReview articlepeer-review


Hereditary canine spinal muscular atrophy is an inherited motor neuron disease that occurs in Brittany Spaniels and has remarkable similarities with human spinal muscular atrophy. Both disorders are characterized by proximal limb and truncal muscle weakness of variable severity. Detailed pathological studies indicate that there is early dysfunction of motor neuron synapses, particularly the neuromuscular junction synapse, prior to motor neuron death. This period of synaptic dysfunction may define a critical window of opportunity for disease reversibility in motor neuron disease.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalUnknown Journal
Volume17 Suppl 3
StatePublished - Dec 2012

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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