Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors

Medicine & Life Sciences

• Serum Response Factor 92%
• sphingosine 1-phosphate 82%
• Smooth Muscle Myocytes 56%
• Cell Differentiation 51%
• myocardin 42%
• Cell Proliferation 41%
• Transcription Factors 17%
• Y 27632 12%
• Smooth Muscle 11%
• Actins 11%
• Growth 6%
• Sphingosine-1-Phosphate Receptors 6%
• fos Genes 6%
• U 0126 5%
• rho-Associated Kinases 5%
• Muscle Proteins 5%
• Mitogen-Activated Protein Kinase Kinases 4%
• Glutathione Transferase 4%
• Reverse Transcriptase Polymerase Chain Reaction 4%
• G-Protein-Coupled Receptors 4%
• Gels 3%
• Endothelial Cells 3%
• Proteins 3%
• Phosphorylation 3%
• Lipids 2%
• Messenger RNA 2%

Chemical Compounds

• Sphingosine 1-Phosphate 100%
• Cofactor 58%
• Y-27632 18%
• EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinase) Inhibitor 7%
• Protein 5%
• Agonist 4%
• Glutathione 4%
• Lipid 3%
• Gel 2%