Sphingolipids in ocular inflammation

Annie Y. Chan; Shivani N. Mann; Hui Chen; Donald U. Stone; Daniel J.J. Carr; Nawajes A. Mandal

doi:10.1007/978-1-4614-3209-8_78

Sphingolipids in ocular inflammation

Annie Y. Chan, Shivani N. Mann, Hui Chen, Donald U. Stone, Daniel J.J. Carr, Nawajes A. Mandal

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Sphingolipids are essential to cell membrane structure and the development and maintenance of neural tissues. The role of bioactive sphingolipids has been established in numerous cellular events, including cell survival, growth, and apoptosis. Ocular inflammatory and autoimmune diseases involve activation and migration of endothelial cells, neovascularization, and infiltration of immune cells into various tissues. Clinically, the impact and role of sphingolipid-mediated signaling is increasingly being appreciated in the pathogenesis and treatment of diseases ranging from multiple sclerosis to neovascularization in age-related macular degeneration and diabetic retinopathy. In this review, we discuss our current knowledge and understanding of sphingolipid metabolism and signaling associated with the pathogenesis of ocular diseases.

Original language	English (US)
Pages (from-to)	623-629
Number of pages	7
Journal	Advances in experimental medicine and biology
Volume	801
DOIs	https://doi.org/10.1007/978-1-4614-3209-8_78
State	Published - 2014

Keywords

Apoptosis
Ceramide
Ocular inflammation
Sphingolipid
Sphingosine-1-phosphate
Uveitis

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4614-3209-8_78

Cite this

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title = "Sphingolipids in ocular inflammation",

abstract = "Sphingolipids are essential to cell membrane structure and the development and maintenance of neural tissues. The role of bioactive sphingolipids has been established in numerous cellular events, including cell survival, growth, and apoptosis. Ocular inflammatory and autoimmune diseases involve activation and migration of endothelial cells, neovascularization, and infiltration of immune cells into various tissues. Clinically, the impact and role of sphingolipid-mediated signaling is increasingly being appreciated in the pathogenesis and treatment of diseases ranging from multiple sclerosis to neovascularization in age-related macular degeneration and diabetic retinopathy. In this review, we discuss our current knowledge and understanding of sphingolipid metabolism and signaling associated with the pathogenesis of ocular diseases.",

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AU - Chan, Annie Y.

AU - Mann, Shivani N.

AU - Chen, Hui

AU - Stone, Donald U.

AU - Carr, Daniel J.J.

AU - Mandal, Nawajes A.

N1 - Publisher Copyright: © Springer Science+Business Media, LLC 2014.

PY - 2014

Y1 - 2014

N2 - Sphingolipids are essential to cell membrane structure and the development and maintenance of neural tissues. The role of bioactive sphingolipids has been established in numerous cellular events, including cell survival, growth, and apoptosis. Ocular inflammatory and autoimmune diseases involve activation and migration of endothelial cells, neovascularization, and infiltration of immune cells into various tissues. Clinically, the impact and role of sphingolipid-mediated signaling is increasingly being appreciated in the pathogenesis and treatment of diseases ranging from multiple sclerosis to neovascularization in age-related macular degeneration and diabetic retinopathy. In this review, we discuss our current knowledge and understanding of sphingolipid metabolism and signaling associated with the pathogenesis of ocular diseases.

AB - Sphingolipids are essential to cell membrane structure and the development and maintenance of neural tissues. The role of bioactive sphingolipids has been established in numerous cellular events, including cell survival, growth, and apoptosis. Ocular inflammatory and autoimmune diseases involve activation and migration of endothelial cells, neovascularization, and infiltration of immune cells into various tissues. Clinically, the impact and role of sphingolipid-mediated signaling is increasingly being appreciated in the pathogenesis and treatment of diseases ranging from multiple sclerosis to neovascularization in age-related macular degeneration and diabetic retinopathy. In this review, we discuss our current knowledge and understanding of sphingolipid metabolism and signaling associated with the pathogenesis of ocular diseases.

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KW - Ceramide

KW - Ocular inflammation

KW - Sphingolipid

KW - Sphingosine-1-phosphate

KW - Uveitis

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Sphingolipids in ocular inflammation

Abstract

Keywords

ASJC Scopus subject areas

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