Spermatogenesis: Its regulation by testosterone and FSH

Barry R. Zirkin

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


It has been clear for decades that testosterone is a necessary prerequisite for the maintenance of established spermatogenesis in the adult testes, and for the restoration of spermatogenesis in testes induced experimentally to become azoospermic. In contrast, the possible involvement of FSH in regulating spermatogenesis in the adult mammal, though also studied extensively, continues to be debated in the literature. The mechanisms by which testosterone and FSH regulate spermatogenesis remain uncertain as well. This review focuses on our current understanding of the involvement of testosterone and of FSH in the maintenance and restoration of spermatogenesis in the adult testes, and discusses the emerging concept that testosterone and FSH serve as cell survival factors.

Original languageEnglish (US)
Pages (from-to)417-421
Number of pages5
JournalSeminars in Cell and Developmental Biology
Issue number4
StatePublished - Aug 1998


  • Spermatogenesis
  • Testosterone FSH

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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