@article{618a9ab7d30b4941845f55c079a251d0,
title = "Specular microscopy of iridocorneal endothelia syndrome",
abstract = "Clinical specular microscopic examination of 17 patients with features common to the iridocorneal endothelial syndrome (including Chandler's syndrome, iris nevus syndrome, and essential iris atrophy) showed pathognomonic endothelial changes and no areas of normal endothelial mosaic. Even in those patients with minimal anterior synechiae, gross central endothelial changes could be found, suggesting that the endothelial changes are primary and not secondary to the iriscorneal adhesions. Specular microscopy of the clinically uninvolved contralateral eye in these patients revealed frequent endothelial cell pleomorphism incommensurate with the patient's age. This study also confirmed the value of the specular microscope for qualitative endothelial observations.",
author = "Hirst, {Lawrence W.} and Quigley, {Harry A.} and Stark, {Walter J.} and Shields, {M. Bruce}",
note = "Funding Information: The iridocorneal endothelial syndrome, which includes progressive essential iris atrophy, Chandler's syndrome, and the iris nevus (Cogan-Reese) syndrome, is characterized by abnormalities of the cornea, anterior chamber angle, and iris.' A defect of the corneal endothelium may be the fundamental change in this spectrum of disease, which leads to corneal edema in some cases and to the growth of a membrane onto the iris.2•3 Contraction of the membrane may cause peripheral anterior synechiae with secondary glaucoma and the variable iris changes. The corneal endothelial defect has a fine beaten-silver appearance by slit-lamp biomicroscopy, and ultrastructural studies of cases with advanced corneal edema show scant, abnormal cells lining a thickened, multilayered Descemet's membrane.v{"} Histologic studies of the corneal endo thelium in the iridocorneal endothelial syndrome have been confined to speci mens from patients with advanced corne al edema. Using specular microscopy, we examined in vivo the corneal endotheli- (Drs. Hirst, Quigley, and Stark), and Duke Universi-ty, Durham, North Carolina (Dr. Shields). This study was presented in part at the meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Florida, Avril 30, 1979. This study was supported in part by Public Health Service Research Grants EY 02476 (Dr. Hirst) and EY 02120 (Dr. Quigley) from the National Eye Institute, National Institutes of Health. Reprint requests to Lawrence W. Hirst, M.D., Wilmer Institute, Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21205.",
year = "1980",
month = jan,
doi = "10.1016/0002-9394(80)90223-8",
language = "English (US)",
volume = "89",
pages = "11--21",
journal = "American journal of ophthalmology",
issn = "0002-9394",
publisher = "Elsevier Inc.",
number = "1",
}