Spectral system denoising in spectroscopic photoacoustic neuroimaging

Research output: Chapter in Book/Report/Conference proceedingConference contribution


A transcranial photoacoustic (PA) imaging can non-invasively quantify graded oxyhemoglobin (HbO2) saturation changes at the superior sagittal sinus (SSS) and brain tissue through intact skull and scalp of large animal models and humans, which strongly implies its potential to address urgent clinical problems to identify brain distress in patients. However, effective signal processing to compensate for substantial transcranial signal attenuation is still desired to secure high imaging contrast. In this study, we present a spectral system denoising scheme for the spectroscopic PA neuroimaging using in vivo neonatal piglets, which well resembles the skull thickness and neurophysiology of term human neonates.

Original languageEnglish (US)
Title of host publicationIUS 2022 - IEEE International Ultrasonics Symposium
PublisherIEEE Computer Society
ISBN (Electronic)9781665466578
StatePublished - 2022
Event2022 IEEE International Ultrasonics Symposium, IUS 2022 - Venice, Italy
Duration: Oct 10 2022Oct 13 2022

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727


Conference2022 IEEE International Ultrasonics Symposium, IUS 2022


  • brain
  • oxyhemoglobin saturation
  • photoacoustic
  • spectral system noise
  • spectral unmixing

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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