TY - GEN
T1 - Spectral system denoising in spectroscopic photoacoustic neuroimaging
AU - Kang, Jeeun
AU - Wu, Yixuan
AU - Graham, Ernest M.
AU - Koehler, Raymond C.
AU - Boctor, Emad
N1 - Funding Information:
The financial support was provided by NIH, NHLBI (R01HL139543); Maryland Innovation Initiative, TEDCO; Louis B Thalheimer Fund for Translational Research; NIH National Institute of Biomedical Imaging and Bioengineering, under Award Number U54EB015408 (Blueprint MedTech Pilot project); and in part by the Congressionally Directed Medical Research Program, Department of Defense, USA (W81XWH-18– 1-0188).
Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - A transcranial photoacoustic (PA) imaging can non-invasively quantify graded oxyhemoglobin (HbO2) saturation changes at the superior sagittal sinus (SSS) and brain tissue through intact skull and scalp of large animal models and humans, which strongly implies its potential to address urgent clinical problems to identify brain distress in patients. However, effective signal processing to compensate for substantial transcranial signal attenuation is still desired to secure high imaging contrast. In this study, we present a spectral system denoising scheme for the spectroscopic PA neuroimaging using in vivo neonatal piglets, which well resembles the skull thickness and neurophysiology of term human neonates.
AB - A transcranial photoacoustic (PA) imaging can non-invasively quantify graded oxyhemoglobin (HbO2) saturation changes at the superior sagittal sinus (SSS) and brain tissue through intact skull and scalp of large animal models and humans, which strongly implies its potential to address urgent clinical problems to identify brain distress in patients. However, effective signal processing to compensate for substantial transcranial signal attenuation is still desired to secure high imaging contrast. In this study, we present a spectral system denoising scheme for the spectroscopic PA neuroimaging using in vivo neonatal piglets, which well resembles the skull thickness and neurophysiology of term human neonates.
KW - brain
KW - oxyhemoglobin saturation
KW - photoacoustic
KW - spectral system noise
KW - spectral unmixing
UR - http://www.scopus.com/inward/record.url?scp=85143749067&partnerID=8YFLogxK
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U2 - 10.1109/IUS54386.2022.9957462
DO - 10.1109/IUS54386.2022.9957462
M3 - Conference contribution
AN - SCOPUS:85143749067
T3 - IEEE International Ultrasonics Symposium, IUS
BT - IUS 2022 - IEEE International Ultrasonics Symposium
PB - IEEE Computer Society
T2 - 2022 IEEE International Ultrasonics Symposium, IUS 2022
Y2 - 10 October 2022 through 13 October 2022
ER -