Abstract
In a previous publication, it was reported that clonidine and morphine caused similar effects in the behavior of EEG of the unrestrained intact dog. In that study, EEG was visually analyzed. In the present study, spectral techniques were used to compare cortical EEG changes induced by morphine and clonidine. In experiments, the variability in randomly chosen EEG sweeps obscured the drug effects and precluded the use of parametric statistics. Therefore, six selected EEG sweeps before intravenous drug infusion and at peak drug effect were analyzed by fast Fourier transform routines to obtain power spectral density estimates at 1 Hz resolution. The spectral estimates were averaged on a computer. Morphine (1 mg/kg) and clonidine (100 mu g/kg) increased total power in the parietal and occipital EEG over the frequency range 0. 3-20 Hz. The increase in spectral power was at least fivefold over the frequency bands 8 - 16 Hz. Both drugs caused an increase in the peak freuency. The quantitative similarity of the morphine and clonidine effects support the hypothesis that these drugs cause EEG synchrony by actions on the same or parallel neural pathways.
| Original language | English (US) |
|---|---|
| Pages | 257-259 |
| Number of pages | 3 |
| State | Published - 1980 |
| Externally published | Yes |
| Event | IEEE/Eng Med Biol Soc Annu Conf 2nd, Front of Eng in Health Care - Washington, DC, USA Duration: Sep 28 1980 → Sep 30 1980 |
Other
| Other | IEEE/Eng Med Biol Soc Annu Conf 2nd, Front of Eng in Health Care |
|---|---|
| City | Washington, DC, USA |
| Period | 9/28/80 → 9/30/80 |
ASJC Scopus subject areas
- General Engineering