TY - JOUR
T1 - Specimen dilution improves sensitivity of the amplified Mycobacterium tuberculosis direct test for smear microscopy-positive respiratory specimens
AU - Guerra, Renata L.
AU - Baker, James F.
AU - Alborz, Roya
AU - Armstrong, Derek T.
AU - Kiehlbauch, Julia A.
AU - Conde, Marcus B.
AU - Dorman, Susan E.
AU - Hooper, Nancy M.
PY - 2008/1
Y1 - 2008/1
N2 - Specimen dilution has been proposed as a strategy to minimize amplified Mycobacterium tuberculosis direct (MTD) test inhibition (N. Pollock, J. Westerling, and A. Sloutsky, Am. J. Clin. Pathol. 126:142-147, 2006; A. Sloutsky, L. L. Han, and B. G. Werner, J. Clin. Microbiol. 42:1547-1551, 2004). We evaluated the impact of respiratory specimen dilution on MTD test accuracy in a public health laboratory. The difference in MTD test sensitivity between the dilution and conventional methods was 15.9% (P = 0.001) for smear microscopy-positive specimens and -3.6% (P = 0.38) for smear microscopy-negative specimens.
AB - Specimen dilution has been proposed as a strategy to minimize amplified Mycobacterium tuberculosis direct (MTD) test inhibition (N. Pollock, J. Westerling, and A. Sloutsky, Am. J. Clin. Pathol. 126:142-147, 2006; A. Sloutsky, L. L. Han, and B. G. Werner, J. Clin. Microbiol. 42:1547-1551, 2004). We evaluated the impact of respiratory specimen dilution on MTD test accuracy in a public health laboratory. The difference in MTD test sensitivity between the dilution and conventional methods was 15.9% (P = 0.001) for smear microscopy-positive specimens and -3.6% (P = 0.38) for smear microscopy-negative specimens.
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U2 - 10.1128/JCM.01313-07
DO - 10.1128/JCM.01313-07
M3 - Article
C2 - 17977991
AN - SCOPUS:38149137102
SN - 0095-1137
VL - 46
SP - 314
EP - 316
JO - Journal of clinical microbiology
JF - Journal of clinical microbiology
IS - 1
ER -