Specificity of affective dynamics of bipolar and major depressive disorder

Emma K. Stapp, Vadim Zipunnikov, Andrew Leroux, Lihong Cui, Mathilde M. Husky, Debangan Dey, Kathleen R. Merikangas

Research output: Contribution to journalArticlepeer-review


Objective: Here, we examine whether the dynamics of the four dimensions of the circumplex model of affect assessed by ecological momentary assessment (EMA) differ among those with bipolar disorder (BD) and major depressive disorder (MDD). Methods: Participants aged 11–85 years (n = 362) reported momentary sad, anxious, active, and energetic dimensional states four times per day for 2 weeks. Individuals with lifetime mood disorder subtypes of bipolar-I, bipolar-II, and MDD derived from a semistructured clinical interview were compared to each other and to controls without a lifetime history of psychiatric disorders. Random effects from individual means, inertias, innovation (residual) variances, and cross-lags across the four affective dimensions simultaneously were derived from multivariate dynamic structural equation models. Results: All mood disorder subtypes were associated with higher levels of sad and anxious mood and lower energy than controls. Those with bipolar-I had lower average activation, and lower energy that was independent of activation, compared to MDD or controls. However, increases in activation were more likely to perpetuate in those with bipolar-I. Bipolar-II was characterized by higher lability of sad and anxious mood compared to bipolar-I and controls but not MDD. Compared to BD and controls, those with MDD exhibited cross-augmentation of sadness and anxiety, and sadness blunted energy. Conclusion: Bipolar-I is more strongly characterized by activation and energy than sad and anxious mood. This distinction has potential implications for both specificity of intervention targets and differential pathways underlying these dynamic affective systems. Confirmation of the longer term stability and generalizability of these findings in future studies is necessary.

Original languageEnglish (US)
Article numbere3134
JournalBrain and Behavior
Issue number9
StatePublished - Sep 2023


  • affective symptoms
  • bipolar disorder
  • depressive disorder
  • ecological momentary assessment
  • emotions
  • major
  • structural equation modeling

ASJC Scopus subject areas

  • Behavioral Neuroscience


Dive into the research topics of 'Specificity of affective dynamics of bipolar and major depressive disorder'. Together they form a unique fingerprint.

Cite this