Specific changes in c-fos expression and colocalization with DNA in identified neuronal nuclei of edible snail following neurotransmitter application

Alexey Shevelkin; O. I. Efimova; V. P. Nikitin; K. V. Anokhin; V. V. Sherstnev

doi:10.1007/s10517-012-1813-6

Specific changes in c-fos expression and colocalization with DNA in identified neuronal nuclei of edible snail following neurotransmitter application

Alexey Shevelkin, O. I. Efimova, V. P. Nikitin, K. V. Anokhin, V. V. Sherstnev

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effects of serotonin and glutamate on c-fos expression and c-Fos colocalization with DNA were immunohistochemically studied in defense behavior command neurons R-LPa2-3 in snail Helix lucorum. Simultaneous neurotransmitter application resulted in increased c-Fosimmunoreactivity and colocalization with DNA-specific stain Hoechst 33342 in LPa2 and RPa2 neurons with specific dynamics for each identified cell. In the nuclei of LPa3 and RPa3 neurons, neurotransmitter application did not significant change the c-Fos level. These findings are indicative of specific spatiotemporal changes in c-fos expression and c-Fos colocalization with DNA in investigated neurons of edible snail under the influence of neurotransmitters.

Original language	English (US)
Pages (from-to)	734-737
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
Volume	153
Issue number	5
DOIs	https://doi.org/10.1007/s10517-012-1813-6
State	Published - Jan 1 2012
Externally published	Yes

Keywords

C-Fos
Defensive behavior command neuron of the snail
Glutamate
Plasticity
Serotonin

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/s10517-012-1813-6

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title = "Specific changes in c-fos expression and colocalization with DNA in identified neuronal nuclei of edible snail following neurotransmitter application",

abstract = "The effects of serotonin and glutamate on c-fos expression and c-Fos colocalization with DNA were immunohistochemically studied in defense behavior command neurons R-LPa2-3 in snail Helix lucorum. Simultaneous neurotransmitter application resulted in increased c-Fosimmunoreactivity and colocalization with DNA-specific stain Hoechst 33342 in LPa2 and RPa2 neurons with specific dynamics for each identified cell. In the nuclei of LPa3 and RPa3 neurons, neurotransmitter application did not significant change the c-Fos level. These findings are indicative of specific spatiotemporal changes in c-fos expression and c-Fos colocalization with DNA in investigated neurons of edible snail under the influence of neurotransmitters.",

keywords = "C-Fos, Defensive behavior command neuron of the snail, Glutamate, Plasticity, Serotonin",

author = "Alexey Shevelkin and Efimova, {O. I.} and Nikitin, {V. P.} and Anokhin, {K. V.} and Sherstnev, {V. V.}",

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T1 - Specific changes in c-fos expression and colocalization with DNA in identified neuronal nuclei of edible snail following neurotransmitter application

AU - Shevelkin, Alexey

AU - Efimova, O. I.

AU - Nikitin, V. P.

AU - Anokhin, K. V.

AU - Sherstnev, V. V.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - The effects of serotonin and glutamate on c-fos expression and c-Fos colocalization with DNA were immunohistochemically studied in defense behavior command neurons R-LPa2-3 in snail Helix lucorum. Simultaneous neurotransmitter application resulted in increased c-Fosimmunoreactivity and colocalization with DNA-specific stain Hoechst 33342 in LPa2 and RPa2 neurons with specific dynamics for each identified cell. In the nuclei of LPa3 and RPa3 neurons, neurotransmitter application did not significant change the c-Fos level. These findings are indicative of specific spatiotemporal changes in c-fos expression and c-Fos colocalization with DNA in investigated neurons of edible snail under the influence of neurotransmitters.

AB - The effects of serotonin and glutamate on c-fos expression and c-Fos colocalization with DNA were immunohistochemically studied in defense behavior command neurons R-LPa2-3 in snail Helix lucorum. Simultaneous neurotransmitter application resulted in increased c-Fosimmunoreactivity and colocalization with DNA-specific stain Hoechst 33342 in LPa2 and RPa2 neurons with specific dynamics for each identified cell. In the nuclei of LPa3 and RPa3 neurons, neurotransmitter application did not significant change the c-Fos level. These findings are indicative of specific spatiotemporal changes in c-fos expression and c-Fos colocalization with DNA in investigated neurons of edible snail under the influence of neurotransmitters.

KW - C-Fos

KW - Defensive behavior command neuron of the snail

KW - Glutamate

KW - Plasticity

KW - Serotonin

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JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

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ER -

Specific changes in c-fos expression and colocalization with DNA in identified neuronal nuclei of edible snail following neurotransmitter application

Abstract

Keywords

ASJC Scopus subject areas

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